Sectors & IndustriesHealthcareBiotechnology
Best Biotech Stocks to Buy Now (2025)
Top biotech stocks in 2025 ranked by overall Zen Rating. "A" Rated stocks have returned an average of +32.52% per year, and are the best biotech stocks to buy now. Learn More.

Industry: Biotechnology
F
Biotech is Zen Rated F and is the 132nd ranked industry out of 145 stock market industries
Learn how the Zen Ratings work
Ticker
Company
Zen Rating
Sentiment
Market Cap
Shares
Institutional %
Insider %
Net Insider (L12M)
Net Insider (L3M)
ONC
BEONE MEDICINES LTD
$35.77B1,438,553,2632.29%32.11%Net BuyingNet Selling
INCY
INCYTE CORP
$20.13B196,322,70377.67%22.33%Net SellingNet Selling
INVA
INNOVIVA INC
$1.55B74,769,06260.33%39.67%Net SellingNet Buying
MDXG
MIMEDX GROUP INC
$1.03B148,102,15946.43%53.57%Net BuyingNet Selling
AUPH
AURINIA PHARMACEUTICALS INC
$2.06B131,840,55949.82%12.61%Net BuyingNet Selling
FOLD
AMICUS THERAPEUTICS INC
$3.05B308,533,54865.98%34.02%Net SellingNet Selling
ANAB
ANAPTYSBIO INC
$1.23B27,688,47042.69%57.31%Net BuyingNet Selling
VCYT
VERACYTE INC
$3.53B79,049,17367.82%32.18%Net SellingNet Selling
ALNY
ALNYLAM PHARMACEUTICALS INC
$60.52B132,113,81882.79%17.21%Net SellingNet Selling
JAZZ
JAZZ PHARMACEUTICALS PLC
$10.31B60,765,11628.42%71.58%Net SellingNet Selling
BCRX
BIOCRYST PHARMACEUTICALS INC
$1.60B210,543,22483.90%16.10%Net SellingNet Selling
MIRM
MIRUM PHARMACEUTICALS INC
$3.52B51,393,57452.35%47.65%Net SellingNet Buying
TBPH
THERAVANCE BIOPHARMA INC
$939.97M50,672,43152.91%47.09%Net SellingNet Selling
ARQT
ARCUTIS BIOTHERAPEUTICS INC
$3.82B122,492,19276.71%23.29%Net SellingNet Selling
FENC
FENNEC PHARMACEUTICALS INC
$212.28M28,116,8293.87%96.13%Net SellingNet Selling
EXEL
EXELIXIS INC
$11.89B268,112,15793.44%5.23%Net SellingNet Selling
RPRX
ROYALTY PHARMA PLC
$22.93B577,238,10756.76%17.37%Net SellingNet Selling
SEPN
SEPTERNA INC
$1.20B44,774,19266.24%33.76%Net BuyingNet Selling
TVTX
TRAVERE THERAPEUTICS INC
$3.13B89,472,32763.49%36.51%Net SellingNet Selling
IDYA
IDEAYA BIOSCIENCES INC
$3.14B87,666,40892.57%7.43%Net Buying
AKBA
AKEBIA THERAPEUTICS INC
$408.66M265,365,99346.61%7.64%Net Selling
VRTX
VERTEX PHARMACEUTICALS INC
$115.56B253,718,83191.37%1.51%Net SellingNet Selling
MNKD
MANNKIND CORP
$1.74B307,070,28135.48%64.52%Net SellingNet Selling
NAGE
NIAGEN BIOSCIENCE INC
$514.75M79,806,13918.41%81.59%Net BuyingNet Buying
ARGX
ARGENX SE
$55.00B61,034,20250.00%0.00%
IMCR
IMMUNOCORE HOLDINGS PLC
$1.96B50,530,41995.81%4.19%Net BuyingNet Buying
VCEL
VERICEL CORP
$1.83B50,574,02691.19%8.81%Net SellingNet Selling
ZVRA
ZEVRA THERAPEUTICS INC
$484.16M56,297,53570.82%22.18%Net SellingNet Buying
XERS
XERIS BIOPHARMA HOLDINGS INC
$1.08B165,924,28958.40%14.81%Net SellingNet Buying
GMAB
GENMAB A
$20.38B64,206,34996.17%0.00%
KNSA
KINIKSA PHARMACEUTICALS INTERNATIONAL PLC
$3.16B75,795,75953.90%9.39%Net SellingNet Selling
TARS
TARSUS PHARMACEUTICALS INC
$3.47B42,449,10573.35%26.65%Net SellingNet Selling
APLS
APELLIS PHARMACEUTICALS INC
$2.99B126,525,21876.30%23.70%Net SellingNet Selling
FBIO
FORTRESS BIOTECH INC
$87.84M31,037,93714.16%48.50%Net BuyingNet Buying
HALO
HALOZYME THERAPEUTICS INC
$7.45B117,597,00077.68%22.32%Net SellingNet Selling
SLNO
SOLENO THERAPEUTICS INC
$2.76B53,710,02535.66%64.34%Net Selling
ADPT
ADAPTIVE BIOTECHNOLOGIES CORP
$2.25B152,665,18862.16%37.84%Net SellingNet Selling
LGND
LIGAND PHARMACEUTICALS INC
$3.64B19,681,72028.36%71.64%Net SellingNet Selling
PBYI
PUMA BIOTECHNOLOGY INC
$267.07M50,391,10761.30%38.70%Net SellingNet Selling
RIGL
RIGEL PHARMACEUTICALS INC
$887.96M18,151,34437.74%62.26%Net Selling
GYRE
GYRE THERAPEUTICS INC
$768.74M96,333,1571.87%98.13%Net Buying
REGN
REGENERON PHARMACEUTICALS INC
$75.50B105,099,46468.36%31.64%Net SellingNet Buying
CPRX
CATALYST PHARMACEUTICALS INC
$2.89B122,912,38784.02%15.79%Net BuyingNet Selling
ACAD
ACADIA PHARMACEUTICALS INC
$4.64B169,181,81772.19%27.81%Net SellingNet Selling
HRMY
HARMONY BIOSCIENCES HOLDINGS INC
$2.29B57,596,35876.18%23.82%Net SellingNet Selling
TGTX
TG THERAPEUTICS INC
$4.88B158,759,45157.29%42.71%Net SellingNet Selling
BMRN
BIOMARIN PHARMACEUTICAL INC
$10.26B192,114,34493.33%1.73%Net SellingNet Selling
EVAX
EVAXION A
$33.16M315,828,6080.42%0.00%
CRMD
CORMEDIX INC
$832.01M78,789,04554.72%8.67%Net SellingNet Buying
ZYME
ZYMEWORKS INC
$2.00B74,836,53452.65%47.35%Net Buying
SPRO
SPERO THERAPEUTICS INC
$127.33M56,339,29520.07%63.90%Net SellingNet Selling
LQDA
LIQUIDIA CORP
$2.99B86,995,48350.36%49.64%Net SellingNet Selling
ENTA
ENANTA PHARMACEUTICALS INC
$421.39M28,862,60157.21%42.79%Net BuyingNet Selling
FHTX
FOGHORN THERAPEUTICS INC
$246.56M56,551,28972.32%14.11%
DOMH
DOMINARI HOLDINGS INC
$62.29M16,012,4357.92%55.42%Net SellingNet Selling
TNGX
TANGO THERAPEUTICS INC
$1.30B134,593,99862.83%37.17%Net SellingNet Selling
KRYS
KRYSTAL BIOTECH INC
$6.79B28,997,51979.21%20.79%Net SellingNet Selling
ARWR
ARROWHEAD PHARMACEUTICALS INC
$8.34B135,809,55881.72%10.13%Net SellingNet Selling
VRDN
VIRIDIAN THERAPEUTICS INC
$3.06B95,442,00874.98%25.02%Net BuyingNet Buying
PTCT
PTC THERAPEUTICS INC
$6.20B80,288,30585.26%14.74%Net SellingNet Selling
BNTX
BIONTECH SE
$23.14B240,455,45020.98%0.00%
SABS
SAB BIOTHERAPEUTICS INC
$189.48M47,606,85135.08%64.92%Net BuyingNet Buying
PRLD
PRELUDE THERAPEUTICS INC
$91.78M62,865,27043.21%52.21%Net BuyingNet Selling
MESO
MESOBLAST LTD
$2.29B1,279,967,1870.28%0.00%
LXRX
LEXICON PHARMACEUTICALS INC
$508.76M363,398,68021.62%78.38%Net Selling
KROS
KEROS THERAPEUTICS INC
$660.81M30,466,06979.10%20.90%Net SellingNet Selling
XOMA
XOMA ROYALTY CORP
$370.38M12,383,10318.97%81.03%Net SellingNet Selling
NBTX
NANOBIOTIX SA
$1.02B48,236,67111.70%0.00%
CLLS
CELLECTIS SA
$342.82M72,325,22911.49%0.00%
AAPG
ASCENTAGE PHARMA GROUP INTERNATIONAL
$2.87B348,999,3200.03%0.00%
UTHR
UNITED THERAPEUTICS CORP
$21.07B43,056,59986.69%13.31%Net SellingNet Selling
ATRA
ATARA BIOTHERAPEUTICS INC
$103.32M7,210,23514.04%85.96%Net BuyingNet Selling
HYPD
HYPERION DEFI INC
$31.50M8,097,6593.65%96.35%
KZIA
KAZIA THERAPEUTICS LTD
$121.82M809,418,7340.02%2.75%
AXSM
AXSOME THERAPEUTICS INC
$7.52B50,412,64061.71%38.29%Net SellingNet Selling
ASMB
ASSEMBLY BIOSCIENCES INC
$553.76M15,817,14050.56%49.44%Net Buying
ASND
ASCENDIS PHARMA A
$12.55B61,098,156100.00%0.00%
NBP
NOVABRIDGE BIOSCIENCES
$342.04M188,108,17815.78%0.00%
BDTX
BLACK DIAMOND THERAPEUTICS INC
$152.12M56,974,91365.78%34.22%Net SellingNet Buying
LYEL
LYELL IMMUNOPHARMA INC
$535.76M21,218,2170.47%99.53%Net BuyingNet Selling
ARDX
ARDELYX INC
$1.45B242,974,30641.73%58.27%Net BuyingNet Selling
CORT
CORCEPT THERAPEUTICS INC
$9.06B105,188,21728.45%71.55%Net SellingNet Selling
CMMB
CHEMOMAB THERAPEUTICS LTD
$15.88M492,409,3200.08%3.44%
PYPD
POLYPID LTD
$62.15M15,654,12918.10%0.00%
ORMP
ORAMED PHARMACEUTICALS INC
$107.07M39,802,45518.18%53.13%
VRCA
VERRICA PHARMACEUTICALS INC
$83.61M9,490,0359.61%90.39%Net BuyingNet Buying
MDWD
MEDIWOUND LTD
$226.68M12,821,43344.91%0.00%
FTRE
FORTREA HOLDINGS INC
$1.32B92,400,00099.48%0.52%Net BuyingNet Selling
ARVN
ARVINAS INC
$821.43M64,224,29474.70%25.30%Net SellingNet Buying
PHAT
PHATHOM PHARMACEUTICALS INC
$1.04B71,138,44065.65%34.35%Net SellingNet Selling
TECH
BIO-TECHNE CORP
$9.61B155,812,70197.61%2.39%Net BuyingNet Selling
NTHI
NEONC TECHNOLOGIES HOLDINGS INC
$178.58M19,474,3038.71%91.29%Net BuyingNet Buying
AGEN
AGENUS INC
$133.65M34,008,3496.28%93.72%Net BuyingNet Buying
GLUE
MONTE ROSA THERAPEUTICS INC
$1.13B65,117,76133.23%66.77%Net Buying
OKYO
OKYO PHARMA LTD
$71.84M37,610,6760.46%99.54%
RLMD
RELMADA THERAPEUTICS INC
$310.93M73,333,62210.55%4.77%Net BuyingNet Buying
ACOG
ALPHA COGNITION INC
$141.98M21,742,10425.95%3.86%Net Buying
SLN
SILENCE THERAPEUTICS PLC
$328.42M141,701,84813.91%0.09%
IVA
INVENTIVA SA
$395.09M95,662,3915.34%0.00%
LXEO
LEXEO THERAPEUTICS INC
$682.43M72,987,32767.63%9.87%Net SellingNet Selling

Biotech Stocks FAQ

What are the best biotech stocks to buy right now in Dec 2025?

According to Zen Ratings, our proprietary rating system that evaluates 115 factors proven to drive growth in stocks and assigns each stock in our system an overall letter grade as well as 7 individual Component Grades for Value, Growth, Momentum, Sentiment, Safety, Financials, and proprietary AI algorithms, the 3 best biotechnology stocks to buy right now are:

1. Beone Medicines (NASDAQ:ONC)


Beone Medicines (NASDAQ:ONC) is the #1 top biotech stock out of 620 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Beone Medicines (NASDAQ:ONC) is: Value: B, Growth: A, Momentum: B, Sentiment: A, Safety: C, Financials: C, and AI: B.

Beone Medicines (NASDAQ:ONC) has a Due Diligence Score of 53, which is 30 points higher than the biotech industry average of 23.

ONC passed 18 out of 33 due diligence checks and has strong fundamentals. Beone Medicines has seen its stock return 60.12% over the past year, overperforming other biotech stocks by 107 percentage points.

Beone Medicines has an average 1 year price target of $390.88, an upside of 21.05% from Beone Medicines's current stock price of $322.90.

Beone Medicines stock has a consensus Strong Buy recommendation according to Wall Street analysts. Of the 8 analysts covering Beone Medicines, 75% have issued a Strong Buy rating, 25% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

2. Incyte (NASDAQ:INCY)


Incyte (NASDAQ:INCY) is the #2 top biotech stock out of 620 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Incyte (NASDAQ:INCY) is: Value: A, Growth: B, Momentum: C, Sentiment: B, Safety: C, Financials: B, and AI: B.

Incyte (NASDAQ:INCY) has a Due Diligence Score of 56, which is 33 points higher than the biotech industry average of 23.

INCY passed 18 out of 33 due diligence checks and has strong fundamentals. Incyte has seen its stock return 36.84% over the past year, overperforming other biotech stocks by 84 percentage points.

Incyte has an average 1 year price target of $96.14, a downside of -6.22% from Incyte's current stock price of $102.52.

Incyte stock has a consensus Strong Buy recommendation according to Wall Street analysts. Of the 14 analysts covering Incyte, 64.29% have issued a Strong Buy rating, 0% have issued a Buy, 28.57% have issued a hold, while 7.14% have issued a Sell rating, and 0% have issued a Strong Sell.

3. Innoviva (NASDAQ:INVA)


Innoviva (NASDAQ:INVA) is the #3 top biotech stock out of 620 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Innoviva (NASDAQ:INVA) is: Value: A, Growth: C, Momentum: C, Sentiment: B, Safety: C, Financials: A, and AI: C.

Innoviva (NASDAQ:INVA) has a Due Diligence Score of 45, which is 22 points higher than the biotech industry average of 23.

INVA passed 14 out of 33 due diligence checks and has strong fundamentals. Innoviva has seen its stock return 9.62% over the past year, overperforming other biotech stocks by 57 percentage points.

Innoviva has an average 1 year price target of $32.00, an upside of 54.29% from Innoviva's current stock price of $20.74.

Innoviva stock has a consensus Buy recommendation according to Wall Street analysts. Of the 4 analysts covering Innoviva, 25% have issued a Strong Buy rating, 50% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 25% have issued a Strong Sell.

What are the biotech stocks with highest dividends?

Out of 4 biotech stocks that have issued dividends in the past year, the 3 biotech stocks with the highest dividend yields are:

1. Dominari Holdings (NASDAQ:DOMH)


Dominari Holdings (NASDAQ:DOMH) has an annual dividend yield of 13.88%, which is 11 percentage points higher than the biotech industry average of 3.23%.

Dominari Holdings's dividend payout ratio of 8.4% indicates that its high dividend yield is sustainable for the long-term.

2. Royalty Pharma (NASDAQ:RPRX)


Royalty Pharma (NASDAQ:RPRX) has an annual dividend yield of 2.21%, which is -1 percentage points lower than the biotech industry average of 3.23%. Royalty Pharma's dividend payout is stable, having never dropped by more than 10% in the last 10 years. Royalty Pharma's dividend has shown consistent growth over the last 10 years.

Royalty Pharma's dividend payout ratio of 49.4% indicates that its dividend yield is sustainable for the long-term.

3. Bio Techne (NASDAQ:TECH)


Bio Techne (NASDAQ:TECH) has an annual dividend yield of 0.52%, which is -3 percentage points lower than the biotech industry average of 3.23%. Bio Techne's dividend payout is not stable, having dropped more than 10% one times in the last 10 years. Bio Techne's dividend has not shown consistent growth over the last 10 years.

Bio Techne's dividend payout ratio of 64% indicates that its dividend yield is sustainable for the long-term.

Why are biotech stocks up?

Biotech stocks were up 0.12% in the last day, and down -0.71% over the last week. Praxis Precision Medicines was the among the top gainers in the biotechnology industry, gaining 30.54% yesterday.

Praxis Precision Medicine shares are trading higher after multiple analyst firms raised their respective price targets on the stock.

What are the most undervalued biotech stocks?

Based on the Valuation rating, one of the 7 components of a stocks overall Zen Ratings grade, which evaluates factors including estimated earnings yield, earnings before interest and taxes/enterprise value, cash flow yield, free cash flow to price, and price-to-earnings growth (PEG ratio), the 3 most undervalued biotech stocks right now are:

1. Harmony Biosciences Holdings (NASDAQ:HRMY)


Harmony Biosciences Holdings (NASDAQ:HRMY) is the most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Harmony Biosciences Holdings has a valuation score of 57, which is 42 points higher than the biotech industry average of 15. It passed 4 out of 7 valuation due diligence checks.

Harmony Biosciences Holdings's stock has gained 18.93% in the past year. It has overperformed other stocks in the biotech industry by 66 percentage points.

2. Puma Biotechnology (NASDAQ:PBYI)


Puma Biotechnology (NASDAQ:PBYI) is the second most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Puma Biotechnology has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

Puma Biotechnology's stock has gained 72.64% in the past year. It has overperformed other stocks in the biotech industry by 120 percentage points.

3. Innoviva (NASDAQ:INVA)


Innoviva (NASDAQ:INVA) is the third most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Innoviva has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

Innoviva's stock has gained 9.62% in the past year. It has overperformed other stocks in the biotech industry by 57 percentage points.

Are biotech stocks a good buy now?

59.39% of biotech stocks rated by analysts are a strong buy right now. On average, analysts expect biotech stocks to rise by 45.27% over the next year.

2.48% of biotech stocks have a Zen Rating of A (Strong Buy), 6.63% of biotech stocks are rated B (Buy), 45.13% are rated C (Hold), 33.54% are rated D (Sell), and 12.22% are rated F (Strong Sell).

What is the average p/e ratio of the biotechnology industry?

The average P/E ratio of the biotechnology industry is 186.51x.
WallStreetZen does not provide financial advice and does not issue recommendations or offers to buy stock or sell any security.

Information is provided 'as-is' and solely for informational purposes and is not advice. WallStreetZen does not bear any responsibility for any losses or damage that may occur as a result of reliance on this data.