| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| James C. Hamilton | Chief Medical Officer | 2026-04-23 | 10,000 | $75.00 | $750.00kSell |
| Daniel Joseph Apel | Chief Financial Officer | 2026-04-22 | 8,730 | $71.92 | $627.86kSell |
| Daniel Joseph Apel | Chief Financial Officer | 2026-04-22 | 1,157 | $70.45 | $81.51kSell |
| Daniel Joseph Apel | Chief Financial Officer | 2026-04-22 | 3,208 | $70.11 | $224.91kSell |
| James C. Hamilton | Chief Medical Officer | 2026-03-05 | 10,000 | $64.19 | $641.90kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 600 | $61.12 | $36.67kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 313 | $68.00 | $21.28kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 900 | $66.01 | $59.41kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 2,700 | $64.44 | $173.99kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 11,842 | $63.84 | $755.99kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Blackrock Inc | 15.22% | 21,318,582 | $1.50B | Institution |
| Vanguard Group Inc | 10.92% | 15,293,121 | $1.08B | Institution |
| Avoro Capital Advisors LLC | 7.59% | 10,625,000 | $749.38M | Institution |
| Fmr LLC | 4.66% | 6,520,408 | $459.88M | Institution |
| State Street Corp | 4.57% | 6,403,830 | $451.66M | Institution |
| David M. Knott | 4.01% | 5,609,690 | $395.65M | Insider |
| Christopher Richard Anzalone | 2.71% | 3,792,739 | $267.50M | Insider |
| Geode Capital Management LLC | 2.33% | 3,264,963 | $230.28M | Institution |
| Slate Path Capital LP | 1.80% | 2,523,500 | $177.98M | Institution |
| Baker Bros Advisors LP | 1.55% | 2,175,645 | $153.45M | Institution |