| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Hongbo Lu | Director | 2026-05-12 | 2,970 | $76.88 | $228.33kSell |
| James C. Hamilton | Chief Medical Officer | 2026-04-23 | 10,000 | $75.00 | $750.00kSell |
| Daniel Joseph Apel | Chief Financial Officer | 2026-04-22 | 8,730 | $71.92 | $627.86kSell |
| Daniel Joseph Apel | Chief Financial Officer | 2026-04-22 | 1,157 | $70.45 | $81.51kSell |
| Daniel Joseph Apel | Chief Financial Officer | 2026-04-22 | 3,208 | $70.11 | $224.91kSell |
| James C. Hamilton | Chief Medical Officer | 2026-03-05 | 10,000 | $64.19 | $641.90kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 313 | $68.00 | $21.28kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 900 | $66.01 | $59.41kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 2,700 | $64.44 | $173.99kSell |
| Patrick 1. Obrien | COO | 2026-01-05 | 11,842 | $63.84 | $755.99kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Blackrock Inc | 12.89% | 18,161,519 | $1.35B | Institution |
| Avoro Capital Advisors LLC | 7.60% | 10,699,999 | $797.36M | Institution |
| Fmr LLC | 5.16% | 7,266,652 | $541.51M | Institution |
| Vanguard Portfolio Management LLC | 5.07% | 7,146,136 | $532.53M | Institution |
| State Street Corp | 4.61% | 6,496,130 | $484.09M | Institution |
| Vanguard Capital Management LLC | 4.28% | 6,032,416 | $449.54M | Institution |
| David M. Knott | 3.98% | 5,609,690 | $418.03M | Insider |
| Geode Capital Management LLC | 3.04% | 4,278,828 | $318.86M | Institution |
| Christopher Richard Anzalone | 2.69% | 3,792,739 | $282.63M | Insider |
| Fred Alger Management LLC | 2.37% | 3,342,493 | $249.08M | Institution |