| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| John W. Kozarich | Director | 2025-12-01 | 30 | $200.02 | $6.00kSell |
| John W. Kozarich | Director | 2025-12-01 | 23 | $199.22 | $4.58kSell |
| John W. Kozarich | Director | 2025-12-01 | 92 | $197.72 | $18.19kSell |
| John W. Kozarich | Director | 2025-12-01 | 4 | $196.35 | $785.38Sell |
| John W. Kozarich | Director | 2025-12-01 | 47 | $195.80 | $9.20kSell |
| John W. Kozarich | Director | 2025-12-01 | 179 | $194.76 | $34.86kSell |
| John W. Kozarich | Director | 2025-12-01 | 92 | $193.86 | $17.83kSell |
| John L. Lamattina | Director | 2025-11-07 | 2,145 | $66.13 | $141.85kBuy |
| Nancy Ryan Gray | Director | 2025-11-07 | 3,015 | $205.45 | $619.43kSell |
| Nancy Ryan Gray | Director | 2025-11-07 | 3,556 | $66.19 | $235.37kBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Bvf Partners L P | 321.79% | 63,334,719 | $11.71B | Insider |
| Tudor Investment Corp Et Al | 80.02% | 15,750,000 | $2.91B | Institution |
| David M. Knott | 64.08% | 12,611,277 | $2.33B | Insider |
| Daniel S. Loeb | 49.56% | 9,754,756 | $1.80B | Insider |
| Investment 10 LLC | 18.20% | 3,582,065 | $662.22M | Insider |
| Blackrock Inc | 14.66% | 2,884,527 | $533.26M | Institution |
| Vanguard Group Inc | 10.55% | 2,076,283 | $383.84M | Institution |
| Janus Henderson Group PLC | 5.30% | 1,042,378 | $192.70M | Institution |
| Macquarie Group Ltd | 3.82% | 751,788 | $138.98M | Institution |
| State Street Corp | 3.81% | 749,360 | $138.53M | Institution |