| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Martina Md Flammer | Chief Medical Officer | 2025-12-01 | 1,559 | $207.73 | $323.85kSell |
| Martina Md Flammer | Chief Medical Officer | 2025-12-01 | 5,886 | $207.03 | $1.22MSell |
| Martina Md Flammer | Chief Medical Officer | 2025-12-01 | 1,450 | $205.98 | $298.67kSell |
| Martina Md Flammer | Chief Medical Officer | 2025-12-01 | 8,895 | $25.83 | $229.76kBuy |
| Elizabeth M. Anderson | Director | 2025-11-24 | 5,000 | $204.58 | $1.02MSell |
| Leo Lee | Director | 2025-11-17 | 14,944 | $195.39 | $2.92MSell |
| Leo Lee | Director | 2025-11-17 | 17,594 | $194.49 | $3.42MSell |
| Leo Lee | Director | 2025-11-17 | 3,212 | $193.51 | $621.55kSell |
| Leo Lee | Director | 2025-11-17 | 24,076 | $196.61 | $4.73MSell |
| Leo Lee | Director | 2025-11-17 | 15,174 | $197.40 | $3.00MSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Jpmorgan Chase Co | 10.81% | 23,047,676 | $4.76B | Institution |
| Richard S. Kollender | 10.28% | 21,924,540 | $4.53B | Insider |
| Darwin Global Management Ltd | 9.59% | 20,457,445 | $4.23B | Institution |
| Vanguard Group Inc | 9.35% | 19,935,820 | $4.12B | Institution |
| Blackrock Inc | 5.80% | 12,364,904 | $2.55B | Institution |
| Fmr LLC | 4.30% | 9,180,963 | $1.90B | Institution |
| Capital International Investors | 3.54% | 7,553,853 | $1.56B | Institution |
| Price T Rowe Associates Inc | 3.25% | 6,931,466 | $1.43B | Institution |
| Baker Bros Advisors LP | 3.14% | 6,703,484 | $1.38B | Institution |
| D E Shaw Co Inc | 2.65% | 5,657,464 | $1.17B | Institution |