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Best Biotech Stocks to Buy Now (2025)

Top biotech stocks in 2025 ranked by overall Zen Rating. "A" Rated stocks have returned an average of +32.52% per year, and are the best biotech stocks to buy now. Learn More.

According to Zen Ratings, our proprietary rating system that evaluates 115 factors proven to drive growth in stocks and assigns each stock in our system an overall letter grade as well as 7 individual Component Grades for Value, Growth, Momentum, Sentiment, Safety, Financials, and proprietary AI algorithms, the 3 best biotechnology stocks to buy right now are:

Theravance Biopharma (NASDAQ:TBPH) is the #1 top biotech stock out of 637 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Theravance Biopharma (NASDAQ:TBPH) is: Value: B, Growth: A, Momentum: C, Sentiment: B, Safety: D, Financials: A, and AI: C.

Theravance Biopharma (NASDAQ:TBPH) has a Due Diligence Score of 39, which is 16 points higher than the biotech industry average of 23.

TBPH passed 12 out of 33 due diligence checks and has average fundamentals. Theravance Biopharma has seen its stock return 69.06% over the past year, overperforming other biotech stocks by 122 percentage points.

Theravance Biopharma has an average 1 year price target of $24.50, an upside of 76.51% from Theravance Biopharma's current stock price of $13.88.

Theravance Biopharma stock has a consensus Strong Buy recommendation according to Wall Street analysts. Of the 2 analysts covering Theravance Biopharma, 100% have issued a Strong Buy rating, 0% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

Rigel Pharmaceuticals (NASDAQ:RIGL) is the #2 top biotech stock out of 637 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Rigel Pharmaceuticals (NASDAQ:RIGL) is: Value: A, Growth: B, Momentum: C, Sentiment: A, Safety: C, Financials: A, and AI: C.

Rigel Pharmaceuticals (NASDAQ:RIGL) has a Due Diligence Score of 40, which is 17 points higher than the biotech industry average of 23.

RIGL passed 13 out of 33 due diligence checks and has average fundamentals. Rigel Pharmaceuticals has seen its stock return 186.72% over the past year, overperforming other biotech stocks by 240 percentage points.

Rigel Pharmaceuticals has an average 1 year price target of $42.00, an upside of 8.11% from Rigel Pharmaceuticals's current stock price of $38.85.

Rigel Pharmaceuticals stock has a consensus Buy recommendation according to Wall Street analysts. Of the 4 analysts covering Rigel Pharmaceuticals, 25% have issued a Strong Buy rating, 25% have issued a Buy, 50% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

Beone Medicines (NASDAQ:ONC) is the #3 top biotech stock out of 637 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Beone Medicines (NASDAQ:ONC) is: Value: B, Growth: A, Momentum: C, Sentiment: B, Safety: C, Financials: C, and AI: B.

Beone Medicines (NASDAQ:ONC) has a Due Diligence Score of 36, which is 13 points higher than the biotech industry average of 23.

ONC passed 12 out of 33 due diligence checks and has average fundamentals. Beone Medicines has seen its stock return 54.18% over the past year, overperforming other biotech stocks by 108 percentage points.

Beone Medicines has an average 1 year price target of $335.78, an upside of 9.71% from Beone Medicines's current stock price of $306.05.

Beone Medicines stock has a consensus Strong Buy recommendation according to Wall Street analysts. Of the 9 analysts covering Beone Medicines, 44.44% have issued a Strong Buy rating, 55.56% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

Out of 6 biotech stocks that have issued dividends in the past year, the 3 biotech stocks with the highest dividend yields are:

Essa Pharma (NASDAQ:EPIX) has an annual dividend yield of 704.6%, which is 602 percentage points higher than the biotech industry average of 102.14%.

Essa Pharma's dividend payout ratio of 0% indicates that its high dividend yield might not be sustainable for the long-term.

Dominari Holdings (NASDAQ:DOMH) has an annual dividend yield of 4.98%, which is -97 percentage points lower than the biotech industry average of 102.14%.

Dominari Holdings's dividend payout ratio of -13.4% indicates that its high dividend yield might not be sustainable for the long-term.

Royalty Pharma (NASDAQ:RPRX) has an annual dividend yield of 2.42%, which is -100 percentage points lower than the biotech industry average of 102.14%. Royalty Pharma's dividend payout is stable, having never dropped by more than 10% in the last 10 years. Royalty Pharma's dividend has shown consistent growth over the last 10 years.

Royalty Pharma's dividend payout ratio of 37.2% indicates that its dividend yield is sustainable for the long-term.

Biotech stocks were down -0.23% in the last day, and down -0.61% over the last week. Outlook Therapeutics was the among the top losers in the biotechnology industry, dropping -21.93% yesterday.

Outlook Therapeutics shares are trading lower after HC Wainwright downgraded the stock from Buy to Neutral and announced a $1 price target.

Based on the Valuation rating, one of the 7 components of a stocks overall Zen Ratings grade, which evaluates factors including estimated earnings yield, earnings before interest and taxes/enterprise value, cash flow yield, free cash flow to price, and price-to-earnings growth (PEG ratio), the 3 most undervalued biotech stocks right now are:

Harmony Biosciences Holdings (NASDAQ:HRMY) is the most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Harmony Biosciences Holdings has a valuation score of 57, which is 42 points higher than the biotech industry average of 15. It passed 4 out of 7 valuation due diligence checks.

Harmony Biosciences Holdings's stock has gained 3.19% in the past year. It has overperformed other stocks in the biotech industry by 57 percentage points.

Puma Biotechnology (NASDAQ:PBYI) is the second most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Puma Biotechnology has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

Puma Biotechnology's stock has gained 105.71% in the past year. It has overperformed other stocks in the biotech industry by 159 percentage points.

United Therapeutics (NASDAQ:UTHR) is the third most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

United Therapeutics has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

United Therapeutics's stock has dropped -15.4% in the past year. It has overperformed other stocks in the biotech industry by 38 percentage points.

54.56% of biotech stocks rated by analysts are a strong buy right now. On average, analysts expect biotech stocks to rise by 86.75% over the next year.

2.73% of biotech stocks have a Zen Rating of A (Strong Buy), 4.4% of biotech stocks are rated B (Buy), 38.99% are rated C (Hold), 34.38% are rated D (Sell), and 19.5% are rated F (Strong Sell).