Sectors & IndustriesHealthcareBiotechnology
Best Biotech Stocks to Buy Now (2025)
Top biotech stocks in 2025 ranked by overall Zen Rating. "A" Rated stocks have returned an average of +32.52% per year, and are the best biotech stocks to buy now. Learn More.

Industry: Biotechnology
F
Biotech is Zen Rated F and is the 131st ranked industry out of 145 stock market industries
Learn how the Zen Ratings work
Ticker
Company
Zen Rating
Growth
Market Cap
Revenue
EBITDA
Earnings
EPS
Rev. Y/Y
Rev. 5Y
Earn. Y/Y
Earn. 5Y
Earnings Date
MDXG
MIMEDX GROUP INC
$1.02B$393.44M$69.21M$40.83M$0.2814.77%8.97%-55.56%N/A
ONC
BEONE MEDICINES LTD
$37.73B$4.97B$318.03M$68.55M$0.0549.92%79.66%N/AN/A
INVA
INNOVIVA INC
$1.62B$388.52M$214.76M$127.34M$1.8910.14%3.81%87.13%-2.45%
AUPH
AURINIA PHARMACEUTICALS INC
$2.13B$265.81M$103.52M$77.84M$0.5820.62%369.11%N/AN/A
JAZZ
JAZZ PHARMACEUTICALS PLC
$10.73B$4.16B$182.64M-$368.48M-$5.994.14%12.77%N/AN/A
INCY
INCYTE CORP
$20.51B$4.81B$1.68B$1.19B$6.0418.09%14.40%3,452.94%N/A
FOLD
AMICUS THERAPEUTICS INC
$3.06B$598.70M$59.28M-$14.06M-$0.0421.28%19.51%N/AN/A
MIRM
MIRUM PHARMACEUTICALS INC
$3.75B$471.79M-$592.00k-$41.42M-$0.8553.66%N/AN/AN/A
EXEL
EXELIXIS INC
$11.84B$2.29B$927.60M$677.90M$2.469.93%19.03%55.70%37.53%
ALNY
ALNYLAM PHARMACEUTICALS INC
$59.61B$3.21B$151.92M$43.57M$0.3153.24%51.59%N/AN/A
ANAB
ANAPTYSBIO INC
$1.15B$169.47M-$82.14M-$84.63M-$2.74196.42%56.59%N/AN/A
VCYT
VERACYTE INC
$3.74B$495.14M$57.00M$30.32M$0.3916.41%34.46%N/AN/A
BCRX
BIOCRYST PHARMACEUTICALS INC
$1.51B$599.82M$83.87M-$8.78M-$0.0545.38%62.14%N/AN/A
HALO
HALOZYME THERAPEUTICS INC
$8.40B$1.24B$845.48M$595.49M$4.8931.19%44.17%59.28%93.56%
TBPH
THERAVANCE BIOPHARMA INC
$1.03B$80.33M$55.37M$29.34M$0.5827.12%-0.56%N/AN/A
ARQT
ARCUTIS BIOTHERAPEUTICS INC
$3.75B$317.93M-$24.00M-$44.32M-$0.35129.21%N/AN/AN/A
FENC
FENNEC PHARMACEUTICALS INC
$230.28M$38.79M-$4.53M-$6.94M-$0.25-21.39%N/AN/AN/A
RPRX
ROYALTY PHARMA PLC
$23.10B$2.35B$1.04B$764.96M$1.763.70%3.20%-31.52%N/A
AKBA
AKEBIA THERAPEUTICS INC
$419.28M$225.07M$25.70M-$15.91M-$0.0832.49%-6.09%N/AN/A
TVTX
TRAVERE THERAPEUTICS INC
$3.17B$435.83M-$22.58M-$88.54M-$1.03114.22%17.57%N/AN/A
IDYA
IDEAYA BIOSCIENCES INC
$3.12B$214.83M-$156.70M-$160.74M-$1.905,377.66%88.75%N/AN/A
VRTX
VERTEX PHARMACEUTICALS INC
$110.02B$11.72B$4.66B$3.68B$14.3110.33%14.37%N/A6.67%
ZVRA
ZEVRA THERAPEUTICS INC
$484.16M$84.39M$67.21M$35.33M$0.48244.60%46.99%N/AN/A
SEPN
SEPTERNA INC
$1.30B$22.05M-$55.32M-$58.81M$13.742,147.20%N/AN/AN/A
GYRE
GYRE THERAPEUTICS INC
$746.58M$107.27M$13.23M$6.65M$0.072.13%41.49%N/AN/A
VCEL
VERICEL CORP
$2.04B$258.72M$29.31M$13.08M$0.2614.05%16.93%271.43%67.03%
RIGL
RIGEL PHARMACEUTICALS INC
$916.46M$282.08M$124.33M$113.30M$6.3379.13%21.72%2,652.17%N/A
IMCR
IMMUNOCORE HOLDINGS PLC
$2.00B$379.59M-$6.14M-$29.23M-$0.5728.10%60.70%N/AN/A
NAGE
NIAGEN BIOSCIENCE INC
$540.29M$124.71M$22.69M$20.43M$0.2736.04%16.99%2,600.00%N/A
PTCT
PTC THERAPEUTICS INC
$6.90B$1.78B$918.90M$751.72M$9.6197.54%37.78%N/AN/A
ARGX
ARGENX SE
$55.66B$1.92M$811.30M$1.51B$25.02-94.62%-50.87%N/AN/A
TARS
TARSUS PHARMACEUTICALS INC
$3.39B$366.10M-$69.62M-$81.16M-$2.01182.44%N/AN/AN/A
PBYI
PUMA BIOTECHNOLOGY INC
$254.48M$212.00M$50.16M$36.98M$0.75-12.96%-2.08%56.25%N/A
SLNO
SOLENO THERAPEUTICS INC
$2.71B$98.68M-$71.40M-$78.45M-$1.85N/AN/AN/AN/A
ADPT
ADAPTIVE BIOTECHNOLOGIES CORP
$3.00B$252.75M-$44.47M-$79.61M-$0.5342.57%22.29%N/AN/A
KNSA
KINIKSA PHARMACEUTICALS INTERNATIONAL PLC
$3.22B$597.97M$53.58M$35.92M$0.4955.68%N/AN/AN/A
MNKD
MANNKIND CORP
$1.64B$313.79M$73.18M$29.23M$0.1017.44%38.00%25.00%N/A
LGND
LIGAND PHARMACEUTICALS INC
$4.00B$251.23M$103.01M$48.58M$2.3164.83%11.86%-12.50%80.67%
FBIO
FORTRESS BIOTECH INC
$87.53M$62.30M$21.58M-$5.34M-$0.11-0.32%7.71%N/AN/A
APLS
APELLIS PHARMACEUTICALS INC
$2.69B$1.02B$93.37M$44.99M$0.3542.11%335.88%N/AN/A
ACAD
ACADIA PHARMACEUTICALS INC
$4.24B$1.05B$287.72M$261.17M$1.5712.69%20.10%101.28%N/A
GMAB
GENMAB A
$20.78B$3.56B$2.00B$1.47B$2.3421.61%18.35%116.79%14.02%
REGN
REGENERON PHARMACEUTICALS INC
$82.00B$14.25B$5.71B$4.58B$43.452.89%12.41%0.49%8.33%2026-01-30
CPRX
CATALYST PHARMACEUTICALS INC
$2.88B$578.20M$323.88M$217.56M$1.7925.56%37.37%43.20%21.00%
XERS
XERIS BIOPHARMA HOLDINGS INC
$1.19B$266.14M$26.62M-$15.64M-$0.1042.05%77.45%N/AN/A
SPRO
SPERO THERAPEUTICS INC
$135.21M$40.55M-$43.55M-$43.84M-$0.79-61.91%29.69%N/AN/A
LQDA
LIQUIDIA CORP
$2.84B$69.22M-$98.20M-$121.85M-$1.44343.41%N/AN/AN/A
TGTX
TG THERAPEUTICS INC
$5.28B$531.90M$115.05M$447.47M$3.07100.88%411.44%N/AN/A
FHTX
FOGHORN THERAPEUTICS INC
$268.62M$24.52M-$63.74M-$72.12M-$1.13-3.91%167.50%N/AN/A
CRMD
CORMEDIX INC
$772.92M$214.30M$112.26M$162.50M$2.271,647.67%300.38%N/AN/A
BDTX
BLACK DIAMOND THERAPEUTICS INC
$217.64M$70.00M$21.84M$21.50M$0.38N/AN/AN/AN/A
HRMY
HARMONY BIOSCIENCES HOLDINGS INC
$2.03B$825.94M$269.64M$185.68M$3.2321.13%49.81%50.23%N/A
BMRN
BIOMARIN PHARMACEUTICAL INC
$10.74B$3.09B$772.70M$520.42M$2.7212.39%10.68%60.00%-10.40%
EVAX
EVAXION A
$37.49M$3.18MN/A-$11.97M-$6.501,042.45%N/AN/AN/A
TNGX
TANGO THERAPEUTICS INC
$1.47B$66.50M-$94.03M-$100.52M-$0.9153.28%N/AN/AN/A
BNTX
BIONTECH SE
$24.80B$3.67B-$69.88M-$664.65M-$2.769.80%79.99%N/AN/A
ENTA
ENANTA PHARMACEUTICALS INC
$407.54M$65.32M-$71.28M-$81.89M-$3.84-3.42%-11.81%N/AN/A2025-12-01
DOMH
DOMINARI HOLDINGS INC
$75.26M$99.59M$110.92M$110.40M$6.40691.09%543.86%N/AN/A
VRDN
VIRIDIAN THERAPEUTICS INC
$3.05B$70.79M-$299.04M-$301.97M-$2.3023,340.07%106.70%N/AN/A
ZYME
ZYMEWORKS INC
$2.00B$134.48M-$43.27M-$63.43M-$0.85116.21%39.84%N/AN/A
KRYS
KRYSTAL BIOTECH INC
$6.32B$373.16M$193.29M$198.91M$6.9054.51%N/A275.00%N/A
XOMA
XOMA ROYALTY CORP
$397.87M$47.11M$26.75M$16.60M$0.81118.02%84.11%N/AN/A
ARWR
ARROWHEAD PHARMACEUTICALS INC
$7.16B$829.45M$133.08M-$1.63M-$0.0123,258.15%56.63%N/AN/A2025-12-01
LXRX
LEXICON PHARMACEUTICALS INC
$519.66M$70.86M-$57.78M-$68.58M-$0.191,255.21%16.85%N/AN/A
MESO
MESOBLAST LTD
$2.21B$17.20M-$78.84M-$102.14M-$0.85191.39%-11.76%N/AN/A
ASMB
ASSEMBLY BIOSCIENCES INC
$597.73M$0.00-$38.49M-$38.55M-$4.79N/A-100.00%N/AN/A
PRLD
PRELUDE THERAPEUTICS INC
$105.61M$6.50M-$108.45M-$111.77M-$1.47116.67%N/AN/AN/A
SABS
SAB BIOTHERAPEUTICS INC
$188.05M$114.70k$22.09M$18.74M-$2.38-92.42%N/AN/AN/A
AXSM
AXSOME THERAPEUTICS INC
$7.64B$561.26M-$211.35M-$229.53M-$4.6765.83%N/AN/AN/A
AAPG
ASCENTAGE PHARMA GROUP INTERNATIONAL
$2.84B$54.40MN/A-$161.45M-$2.02-56.32%N/AN/AN/A
HYPD
HYPERION DEFI INC
$36.52M$345.32k-$23.12M-$26.40M-$21.24984.82%N/AN/AN/A
NBTX
NANOBIOTIX SA
$998.02M$11.95M-$43.75M-$60.76M-$1.28-73.67%N/AN/AN/A
CLLS
CELLECTIS SA
$366.69M$82.55M$12.03M-$35.35M-$0.39129.05%2.74%N/AN/A
ARVN
ARVINAS INC
$808.26M$312.30M-$53.10M-$58.50M-$0.8193.85%66.37%N/AN/A
ASND
ASCENDIS PHARMA A
$12.97B$751.80M-$2.15M-$270.86M-$4.49109.08%134.95%N/AN/A
ATRA
ATARA BIOTHERAPEUTICS INC
$108.87M$151.93M$38.25M$23.40M$3.3451.27%N/AN/AN/A
PYPD
POLYPID LTD
$61.83M$0.00-$31.55M-$34.53M$9.01N/AN/A-66.70%N/A
UTHR
UNITED THERAPEUTICS CORP
$20.93B$3.13B$1.77B$1.27B$28.4813.50%17.29%17.15%21.79%
FTRE
FORTREA HOLDINGS INC
$1.17B$2.76B-$828.20M-$1.01B-$11.241.88%N/AN/AN/A
CMMB
CHEMOMAB THERAPEUTICS LTD
$16.77M$0.00N/A-$10.09M-$2.64N/AN/AN/AN/A
MDWD
MEDIWOUND LTD
$229.76M$20.93M-$15.43M-$20.60M-$1.856.15%0.39%N/AN/A
ARDX
ARDELYX INC
$1.41B$398.23M-$31.96M-$56.55M-$0.2358.12%118.41%N/AN/A
ORMP
ORAMED PHARMACEUTICALS INC
$113.44M$2.00M$43.10M$43.85M$1.03N/A-5.90%836.36%N/A
VRCA
VERRICA PHARMACEUTICALS INC
$86.36M$30.83M-$16.39M-$26.01M-$2.81234.73%N/AN/AN/A
ADMA
ADMA BIOLOGICS INC
$4.56B$488.56M$172.13M$209.45M$0.8827.62%64.71%203.45%N/A
LYEL
LYELL IMMUNOPHARMA INC
$509.24M$34.00k-$311.49M-$325.66M-$23.02-43.33%N/AN/AN/A
JANX
JANUX THERAPEUTICS INC
$2.05B$10.00M-$99.82M-$101.90M-$1.67-23.37%N/AN/AN/A
OKYO
OKYO PHARMA LTD
$73.72M$0.00-$7.09M-$4.71M-$0.20N/AN/AN/AN/A2025-12-22
KZIA
KAZIA THERAPEUTICS LTD
$85.39M$1.19M-$13.97M-$13.44M-$2.46-27.25%10.46%N/AN/A
NBP
NOVABRIDGE BIOSCIENCES
$314.22M$0.00N/A-$38.21M-$0.48-100.00%-100.00%N/AN/A
KROS
KEROS THERAPEUTICS INC
$532.55M$246.72M$74.95M$64.45M$1.6037,798.31%150.53%N/AN/A
NTHI
NEONC TECHNOLOGIES HOLDINGS INC
$174.30MN/AN/AN/AN/AN/AN/AN/AN/A
AGEN
AGENUS INC
$155.08M$106.83M$37.44M-$35.38M-$1.97-33.41%3.17%N/AN/A
CGEN
COMPUGEN LTD
$145.92M$6.90MN/A-$27.62M-$0.30-88.47%N/AN/AN/A
CORT
CORCEPT THERAPEUTICS INC
$8.35B$741.17M$65.98M$104.65M$1.0017.92%15.79%-26.47%1.03%
XLO
XILIO THERAPEUTICS INC
$39.80M$31.80M-$56.90M-$58.49M-$0.63588.40%N/AN/AN/A
ALDX
ALDEYRA THERAPEUTICS INC
$329.69M$0.00-$41.04M-$43.19M-$0.73N/AN/AN/AN/A
PHAT
PHATHOM PHARMACEUTICALS INC
$1.11B$147.19M-$203.56M-$274.55M-$3.77460.30%N/AN/AN/A
LXEO
LEXEO THERAPEUTICS INC
$719.66M$0.00-$102.80M-$104.97M-$2.70N/AN/AN/AN/A2025-12-15
RAPT
RAPT THERAPEUTICS INC
$783.66M$0.00-$102.44M-$105.64M-$11.64N/A-100.00%N/AN/A

Biotech Stocks FAQ

What are the best biotech stocks to buy right now in Dec 2025?

According to Zen Ratings, our proprietary rating system that evaluates 115 factors proven to drive growth in stocks and assigns each stock in our system an overall letter grade as well as 7 individual Component Grades for Value, Growth, Momentum, Sentiment, Safety, Financials, and proprietary AI algorithms, the 3 best biotechnology stocks to buy right now are:

1. Mimedx Group (NASDAQ:MDXG)


Mimedx Group (NASDAQ:MDXG) is the #1 top biotech stock out of 621 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Mimedx Group (NASDAQ:MDXG) is: Value: B, Growth: B, Momentum: C, Sentiment: A, Safety: C, Financials: A, and AI: C.

Mimedx Group (NASDAQ:MDXG) has a Due Diligence Score of 42, which is 19 points higher than the biotech industry average of 23.

MDXG passed 13 out of 33 due diligence checks and has strong fundamentals. Mimedx Group has seen its stock lose -25.62% over the past year, overperforming other biotech stocks by 23 percentage points.

Mimedx Group has an average 1 year price target of $12.00, an upside of 74.42% from Mimedx Group's current stock price of $6.88.

Mimedx Group stock has a consensus Strong Buy recommendation according to Wall Street analysts. Of the 1 analyst covering Mimedx Group, 100% have issued a Strong Buy rating, 0% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

2. Beone Medicines (NASDAQ:ONC)


Beone Medicines (NASDAQ:ONC) is the #2 top biotech stock out of 621 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Beone Medicines (NASDAQ:ONC) is: Value: B, Growth: A, Momentum: B, Sentiment: A, Safety: C, Financials: C, and AI: B.

Beone Medicines (NASDAQ:ONC) has a Due Diligence Score of 53, which is 30 points higher than the biotech industry average of 23.

ONC passed 18 out of 33 due diligence checks and has strong fundamentals. Beone Medicines has seen its stock return 58.42% over the past year, overperforming other biotech stocks by 107 percentage points.

Beone Medicines has an average 1 year price target of $390.88, an upside of 14.76% from Beone Medicines's current stock price of $340.61.

Beone Medicines stock has a consensus Strong Buy recommendation according to Wall Street analysts. Of the 8 analysts covering Beone Medicines, 75% have issued a Strong Buy rating, 25% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

3. Innoviva (NASDAQ:INVA)


Innoviva (NASDAQ:INVA) is the #3 top biotech stock out of 621 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Innoviva (NASDAQ:INVA) is: Value: A, Growth: C, Momentum: C, Sentiment: B, Safety: C, Financials: A, and AI: C.

Innoviva (NASDAQ:INVA) has a Due Diligence Score of 45, which is 22 points higher than the biotech industry average of 23.

INVA passed 14 out of 33 due diligence checks and has strong fundamentals. Innoviva has seen its stock return 14.43% over the past year, overperforming other biotech stocks by 63 percentage points.

Innoviva has an average 1 year price target of $32.00, an upside of 47.26% from Innoviva's current stock price of $21.73.

Innoviva stock has a consensus Buy recommendation according to Wall Street analysts. Of the 4 analysts covering Innoviva, 25% have issued a Strong Buy rating, 50% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 25% have issued a Strong Sell.

What are the biotech stocks with highest dividends?

Out of 4 biotech stocks that have issued dividends in the past year, the 3 biotech stocks with the highest dividend yields are:

1. Dominari Holdings (NASDAQ:DOMH)


Dominari Holdings (NASDAQ:DOMH) has an annual dividend yield of 11.49%, which is 9 percentage points higher than the biotech industry average of 2.81%.

Dominari Holdings's dividend payout ratio of 8.4% indicates that its high dividend yield is sustainable for the long-term.

2. Royalty Pharma (NASDAQ:RPRX)


Royalty Pharma (NASDAQ:RPRX) has an annual dividend yield of 2.2%, which is -1 percentage points lower than the biotech industry average of 2.81%. Royalty Pharma's dividend payout is stable, having never dropped by more than 10% in the last 10 years. Royalty Pharma's dividend has shown consistent growth over the last 10 years.

Royalty Pharma's dividend payout ratio of 49.4% indicates that its dividend yield is sustainable for the long-term.

3. Bio Techne (NASDAQ:TECH)


Bio Techne (NASDAQ:TECH) has an annual dividend yield of 0.5%, which is -2 percentage points lower than the biotech industry average of 2.81%. Bio Techne's dividend payout is not stable, having dropped more than 10% one times in the last 10 years. Bio Techne's dividend has not shown consistent growth over the last 10 years.

Bio Techne's dividend payout ratio of 64% indicates that its dividend yield is sustainable for the long-term.

Why are biotech stocks up?

Biotech stocks were up 0.19% in the last day, and up 4.45% over the last week. Pasithea Therapeutics was the among the top gainers in the biotechnology industry, gaining 38.68% yesterday.

Pasithea Therapeutics shares are trading higher after the company priced an 80M-share public offering at $0.75 per share.

What are the most undervalued biotech stocks?

Based on the Valuation rating, one of the 7 components of a stocks overall Zen Ratings grade, which evaluates factors including estimated earnings yield, earnings before interest and taxes/enterprise value, cash flow yield, free cash flow to price, and price-to-earnings growth (PEG ratio), the 3 most undervalued biotech stocks right now are:

1. Harmony Biosciences Holdings (NASDAQ:HRMY)


Harmony Biosciences Holdings (NASDAQ:HRMY) is the most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Harmony Biosciences Holdings has a valuation score of 71, which is 56 points higher than the biotech industry average of 15. It passed 5 out of 7 valuation due diligence checks.

Harmony Biosciences Holdings's stock has gained 1.79% in the past year. It has overperformed other stocks in the biotech industry by 51 percentage points.

2. Puma Biotechnology (NASDAQ:PBYI)


Puma Biotechnology (NASDAQ:PBYI) is the second most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Puma Biotechnology has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

Puma Biotechnology's stock has gained 48.97% in the past year. It has overperformed other stocks in the biotech industry by 98 percentage points.

3. Innoviva (NASDAQ:INVA)


Innoviva (NASDAQ:INVA) is the third most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Innoviva has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

Innoviva's stock has gained 14.43% in the past year. It has overperformed other stocks in the biotech industry by 63 percentage points.

Are biotech stocks a good buy now?

59.21% of biotech stocks rated by analysts are a strong buy right now. On average, analysts expect biotech stocks to rise by 43.31% over the next year.

3.33% of biotech stocks have a Zen Rating of A (Strong Buy), 6.86% of biotech stocks are rated B (Buy), 45.74% are rated C (Hold), 31.19% are rated D (Sell), and 12.89% are rated F (Strong Sell).

What is the average p/e ratio of the biotechnology industry?

The average P/E ratio of the biotechnology industry is 212.11x.
WallStreetZen does not provide financial advice and does not issue recommendations or offers to buy stock or sell any security.

Information is provided 'as-is' and solely for informational purposes and is not advice. WallStreetZen does not bear any responsibility for any losses or damage that may occur as a result of reliance on this data.