| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-07-01 | 3,830 | $82.76 | $316.97kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-06-24 | 266 | $84.25 | $22.41kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-06-24 | 266 | $44.25 | $11.77kBuy |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-04-01 | 3,782 | $70.11 | $265.16kSell |
| Matthew Pauls | Director | 2025-03-28 | 5,937 | $4.60 | $27.31kBuy |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-03-28 | 2,691 | $33.60 | $90.42kBuy |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-03-28 | 3,394 | $67.46 | $228.95kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-03-28 | 12,324 | $68.92 | $849.38kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-03-28 | 9,253 | $69.52 | $643.25kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-03-28 | 2,691 | $73.60 | $198.06kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Andrew Sinclair | 52.76% | 28,335,695 | $1.43B | Insider |
| Abingworth LLP | 46.53% | 24,991,874 | $1.26B | Insider |
| Edgar Engleman | 42.37% | 22,756,018 | $1.15B | Insider |
| James Walter Glasheen | 15.77% | 8,470,180 | $427.32M | Insider |
| Fmr LLC | 14.89% | 7,999,682 | $403.58M | Institution |
| Stuart J. Collinson | 13.50% | 7,252,746 | $365.90M | Insider |
| Forward V Associates LLC | 13.36% | 7,173,976 | $361.93M | Insider |
| Janus Henderson Group PLC | 11.28% | 6,056,339 | $305.54M | Institution |
| Perceptive Advisors LLC | 9.34% | 5,018,997 | $253.21M | Insider |
| Vivo Opportunity LLC | 8.30% | 4,458,294 | $224.92M | Insider |