| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Kristen Yen | Officer title SVP Global Clinical Operations and Patient Advocacy | 2025-12-15 | 904 | $49.95 | $45.15kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-12-15 | 904 | $49.95 | $45.15kSell |
| Bhatnagar Anish | CHIEF EXECUTIVE OFFICER | 2025-12-15 | 7,620 | $49.95 | $380.62kSell |
| Meredith Manning | Chief Commercial Officer | 2025-12-15 | 1,922 | $49.95 | $96.00kSell |
| James H. MacKaness | CHIEF FINANCIAL OFFICER | 2025-12-15 | 2,013 | $49.95 | $100.55kSell |
| Michael F. Huang | Sr. VP of Clinical Development | 2025-12-15 | 812 | $49.95 | $40.56kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-07-01 | 3,830 | $82.76 | $316.97kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-06-24 | 266 | $44.25 | $11.77kBuy |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-06-24 | 266 | $84.25 | $22.41kSell |
| Patricia C. Hirano | Officer title Senior Vice President Regulatory Affairs | 2025-04-01 | 3,782 | $70.11 | $265.16kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Andrew Sinclair | 52.76% | 28,335,695 | $1.15B | Insider |
| Abingworth LLP | 46.53% | 24,991,874 | $1.01B | Insider |
| Edgar Engleman | 42.37% | 22,756,018 | $922.76M | Insider |
| James Walter Glasheen | 15.77% | 8,470,180 | $343.47M | Insider |
| Fmr LLC | 14.89% | 7,999,682 | $324.39M | Institution |
| Stuart J. Collinson | 13.50% | 7,252,746 | $294.10M | Insider |
| Forward V Associates LLC | 13.36% | 7,173,976 | $290.90M | Insider |
| Janus Henderson Group PLC | 11.28% | 6,056,339 | $245.58M | Institution |
| Perceptive Advisors LLC | 9.34% | 5,018,997 | $203.52M | Insider |
| Vivo Opportunity LLC | 8.30% | 4,458,294 | $180.78M | Insider |