| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2026-01-05 | 2,490 | $28.98 | $72.17kSell |
| Howard G. Welgus | Director | 2026-01-02 | 10,000 | $28.96 | $289.61kSell |
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2025-12-31 | 1,156 | $29.39 | $33.97kSell |
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2025-12-31 | 541 | $28.81 | $15.59kSell |
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2025-12-15 | 11,500 | $28.94 | $332.86kSell |
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2025-12-15 | 11,500 | $3.64 | $41.86kBuy |
| Howard G. Welgus | Director | 2025-12-01 | 10,000 | $30.21 | $302.13kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2025-12-01 | 1,657 | $30.23 | $50.09kSell |
| Suejean Lin | Director | 2025-11-24 | 7,220 | $7.51 | $54.22kBuy |
| Suejean Lin | Director | 2025-11-24 | 25,272 | $30.78 | $777.95kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Patrick J. Heron | 15.86% | 19,430,454 | $511.60M | Insider |
| Jennison Associates LLC | 10.00% | 12,254,119 | $322.65M | Institution |
| Rubric Capital Management LP | 8.78% | 10,749,457 | $283.03M | Institution |
| Suvretta Capital Management LLC | 8.55% | 10,478,000 | $275.89M | Institution |
| Frazier Life Sciences Management LP | 8.06% | 9,874,511 | $260.00M | Institution |
| Frazier Life Sciences VIII LP | 7.22% | 8,838,534 | $232.72M | Insider |
| Blackrock Inc | 7.00% | 8,573,995 | $225.75M | Institution |
| Vanguard Group Inc | 5.83% | 7,146,090 | $188.16M | Institution |
| Polar Capital Holdings PLC | 4.33% | 5,298,754 | $139.52M | Institution |
| State Street Corp | 3.79% | 4,641,315 | $122.21M | Institution |