| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2026-02-04 | 9,794 | $25.81 | $252.74kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2026-02-02 | 4,714 | $25.63 | $120.82kSell |
| Latha Vairavan | SVP Chief Financial Officer | 2026-02-02 | 1,320 | $25.50 | $33.66kSell |
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2026-02-02 | 3,675 | $25.50 | $93.71kSell |
| Larry Todd Edwards | Reporting Persons title EVP Chief Commercial Officer | 2026-02-02 | 2,052 | $25.50 | $52.32kSell |
| Howard G. Welgus | Director | 2026-02-02 | 10,000 | $25.05 | $250.48kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2026-02-02 | 7,983 | $25.50 | $203.55kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2026-02-02 | 8,562 | $24.97 | $213.79kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2026-02-02 | 19,379 | $25.24 | $489.13kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2026-02-02 | 19,833 | $25.50 | $505.70kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Patrick J. Heron | 15.86% | 19,430,454 | $506.75M | Insider |
| Jennison Associates LLC | 10.00% | 12,254,119 | $319.59M | Institution |
| Rubric Capital Management LP | 8.78% | 10,749,457 | $280.35M | Institution |
| Suvretta Capital Management LLC | 8.55% | 10,478,000 | $273.27M | Institution |
| Frazier Life Sciences Management LP | 8.06% | 9,874,511 | $257.53M | Institution |
| Frazier Life Sciences VIII LP | 7.22% | 8,838,534 | $230.51M | Insider |
| Blackrock Inc | 7.00% | 8,573,995 | $223.61M | Institution |
| Vanguard Group Inc | 5.83% | 7,146,090 | $186.37M | Institution |
| Polar Capital Holdings PLC | 4.33% | 5,298,754 | $138.19M | Institution |
| State Street Corp | 3.79% | 4,641,315 | $121.05M | Institution |