| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2025-11-05 | 3,864 | $23.72 | $91.64kSell |
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2025-11-03 | 15 | $25.40 | $381.00Sell |
| Patrick Burnett | Reporting Persons Title Executive Vice President and Chief Medical Officer | 2025-11-03 | 2,607 | $24.71 | $64.42kSell |
| Howard G. Welgus | Director | 2025-11-03 | 10,000 | $25.27 | $252.67kSell |
| Latha Vairavan | SVP Chief Financial Officer | 2025-11-03 | 88 | $24.72 | $2.18kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2025-11-03 | 43 | $25.40 | $1.09kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2025-11-03 | 7,165 | $24.71 | $177.06kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-11-03 | 11,478 | $24.71 | $283.64kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-11-03 | 69 | $25.40 | $1.75kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-10-28 | 40,000 | $25.03 | $1.00MSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Patrick J. Heron | 15.86% | 19,430,454 | $487.70M | Insider |
| Suvretta Capital Management LLC | 9.42% | 11,535,582 | $289.54M | Institution |
| Jennison Associates LLC | 9.07% | 11,109,405 | $278.85M | Institution |
| Rubric Capital Management LP | 8.78% | 10,749,457 | $269.81M | Institution |
| Frazier Life Sciences Management LP | 8.06% | 9,874,511 | $247.85M | Institution |
| Frazier Life Sciences VIII LP | 7.22% | 8,838,534 | $221.85M | Insider |
| Blackrock Inc | 6.97% | 8,532,761 | $214.17M | Institution |
| Vanguard Group Inc | 5.75% | 7,049,099 | $176.93M | Institution |
| Polar Capital Holdings PLC | 4.09% | 5,006,475 | $125.66M | Institution |
| State Street Corp | 3.70% | 4,526,937 | $113.63M | Institution |