| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Howard G. Welgus | Director | 2025-12-01 | 10,000 | $30.21 | $302.13kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2025-12-01 | 1,657 | $30.23 | $50.09kSell |
| Suejean Lin | Director | 2025-11-24 | 18,052 | $8.63 | $155.79kBuy |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-11-24 | 48,945 | $30.36 | $1.49MSell |
| Suejean Lin | Director | 2025-11-24 | 25,272 | $30.78 | $777.95kSell |
| Suejean Lin | Director | 2025-11-24 | 7,220 | $7.51 | $54.22kBuy |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-11-21 | 1,055 | $30.00 | $31.65kSell |
| Halley E. Gilbert | Director | 2025-11-20 | 12,220 | $7.51 | $91.77kBuy |
| Halley E. Gilbert | Director | 2025-11-20 | 16,532 | $27.55 | $455.44kSell |
| Masaru Matsuda | Reporting Persons title SVP General Counsel and Corporate Secretary | 2025-11-19 | 1,561 | $28.50 | $44.49kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Patrick J. Heron | 15.86% | 19,430,454 | $606.23M | Insider |
| Jennison Associates LLC | 10.00% | 12,254,119 | $382.33M | Institution |
| Rubric Capital Management LP | 8.78% | 10,749,457 | $335.38M | Institution |
| Suvretta Capital Management LLC | 8.55% | 10,478,000 | $326.91M | Institution |
| Frazier Life Sciences Management LP | 8.06% | 9,874,511 | $308.08M | Institution |
| Frazier Life Sciences VIII LP | 7.22% | 8,838,534 | $275.76M | Insider |
| Blackrock Inc | 7.00% | 8,573,995 | $267.51M | Institution |
| Vanguard Group Inc | 5.83% | 7,146,090 | $222.96M | Institution |
| Polar Capital Holdings PLC | 4.33% | 5,298,754 | $165.32M | Institution |
| State Street Corp | 3.79% | 4,641,315 | $144.81M | Institution |