| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Howard G. Welgus | Director | 2026-04-01 | 10,000 | $23.88 | $238.80kSell |
| Masaru Matsuda | Reporting Persons title EVP Chief Legal Officer | 2026-03-02 | 6,553 | $25.16 | $164.87kSell |
| Howard G. Welgus | Director | 2026-03-02 | 10,000 | $25.65 | $256.52kSell |
| Masaru Matsuda | Reporting Persons title EVP Chief Legal Officer | 2026-03-02 | 193 | $25.91 | $5.00kSell |
| Masaru Matsuda | Reporting Persons title EVP Chief Legal Officer | 2026-03-02 | 1,987 | $25.70 | $51.07kSell |
| Keith R. Leonard | Director | 2026-03-02 | 39,272 | $25.39 | $997.19kSell |
| Keith R. Leonard | Director | 2026-03-02 | 12,220 | $7.51 | $91.77kBuy |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2026-03-02 | 1,068 | $25.91 | $27.68kSell |
| Keith R. Leonard | Director | 2026-03-02 | 27,052 | $8.63 | $233.46kBuy |
| Latha Vairavan | SVP Chief Financial Officer | 2026-03-02 | 2,772 | $25.16 | $69.74kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Patrick J. Heron | 15.67% | 19,430,454 | $477.41M | Insider |
| Suvretta Capital Management LLC | 9.65% | 11,964,000 | $293.96M | Institution |
| Frazier Life Sciences Management LP | 7.96% | 9,874,511 | $242.62M | Institution |
| Blackrock Inc | 7.34% | 9,099,579 | $223.58M | Institution |
| Frazier Life Sciences VIII LP | 7.13% | 8,838,534 | $217.16M | Insider |
| Rubric Capital Management LP | 6.67% | 8,271,577 | $203.23M | Institution |
| Vanguard Group Inc | 5.85% | 7,253,936 | $178.23M | Institution |
| Jennison Associates LLC | 5.45% | 6,758,006 | $166.04M | Institution |
| Polar Capital Holdings PLC | 4.48% | 5,556,169 | $136.52M | Institution |
| State Street Corp | 4.42% | 5,488,301 | $134.85M | Institution |