| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Larry Todd Edwards | Reporting Persons title EVP Chief Commercial Officer | 2025-10-02 | 4,207 | $19.99 | $84.09kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-10-02 | 20,739 | $20.04 | $415.57kSell |
| Larry Todd Edwards | Reporting Persons title EVP Chief Commercial Officer | 2025-10-02 | 297 | $20.78 | $6.17kSell |
| Howard G. Welgus | Director | 2025-10-01 | 9,538 | $18.92 | $180.49kSell |
| Howard G. Welgus | Director | 2025-10-01 | 462 | $18.92 | $8.74kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-10-01 | 15,000 | $18.91 | $283.70kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-10-01 | 9,261 | $20.02 | $185.37kSell |
| Howard G. Welgus | Director | 2025-10-01 | 9,538 | $1.68 | $16.03kBuy |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-09-09 | 504 | $17.52 | $8.83kSell |
| Todd Watanabe | Reporting Persons title President and Chief Executive Officer | 2025-09-08 | 9,625 | $17.54 | $168.80kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Patrick J. Heron | 16.20% | 19,430,454 | $390.16M | Insider |
| Suvretta Capital Management LLC | 9.62% | 11,535,582 | $231.63M | Institution |
| Jennison Associates LLC | 9.27% | 11,109,405 | $223.08M | Institution |
| Rubric Capital Management LP | 8.96% | 10,749,457 | $215.85M | Institution |
| Frazier Life Sciences Management LP | 8.24% | 9,874,511 | $198.28M | Institution |
| Frazier Life Sciences VIII LP | 7.37% | 8,838,534 | $177.48M | Insider |
| Blackrock Inc | 7.12% | 8,532,761 | $171.34M | Institution |
| Vanguard Group Inc | 5.88% | 7,049,099 | $141.55M | Institution |
| Polar Capital Holdings PLC | 4.18% | 5,006,475 | $100.53M | Institution |
| State Street Corp | 3.78% | 4,526,937 | $90.90M | Institution |