How to Buy Upstream Bio Stock

Upstream Bio Inc

Upstream Bio, Inc. , a clinical-stage biotechnology company, develops treatments for inflammatory diseases that focuses on severe respiratory disorders.

Upstream Bio stock last closed at $22.28, up 2.72% from the previous day, and has decreased 5.71% in one year. It has overperformed other stocks in the Biotechnology industry by 0.21 percentage points. Upstream Bio stock is currently +333.46% from its 52-week low of $5.14, and -24.37% from its 52-week high of $29.46.

At the moment, there are 53.91M shares of UPB outstanding. The market capitalization of UPB is $1.20B. In the last 24 hours, 391,000 UPB shares were traded.

How to Buy Upstream Bio Stock

Wondering how to invest in Upstream Bio stock? Here's how.

  1. Figure out where to buy Upstream Bio stock: You need to pick an online brokerage, but don't worry - we've analyzed dozens of online stock brokerages and apps to help you determine where to buy Upstream Bio stock.
  2. Open a brokerage account: Sign up for 0% commission trading with the highest-rated brokerage we've selected.
  3. Deposit funds into your investment account: Choose your method of payment and add your details.
  4. Research Upstream Bio stock: The Upstream Bio ticker symbol is UPB. Is Upstream Bio stock a good investment? Should you buy shares of UPB? How do UPB's underlying business fundamentals look? Do top analysts think Upstream Bio is a good buy? Why has UPB's stock price moved recently? (Hint: Our stock market analysis website can help you figure out if UPB is a good stock to buy).
  5. Execute your UPB trade: Decide if you will purchase UPB shares at the current market price or use a limit order to purchase UPB shares at a given price.
  6. Keep an eye on your investment in UPB: Create a watchlist to keep track of your new investment in Upstream Bio shares.

Step 1: Figure out where to buy Upstream Bio stock

You need an online brokerage account to access the NASDAQ market and buy UPB shares.

A brokerage account is an investment account that enables you to buy and sell a variety of investments, including stocks, bonds, mutual funds, and ETFs.

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Step 2: Open a brokerage account

Now that you've picked the right brokerage, you'll need to fill out some personal details so you are able to buy UPB today.

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  1. Submit your information by clicking the "Create Account" button.
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Step 3: Deposit funds into your investment account

Now that you have created your account on one of the most highly reviewed stock trading apps, you can securely and quickly fund your account:

Watch the video below for more details transferring money into your brokerage account.

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Step 4: Research Upstream Bio stock

Once you have decided on the best place to buy Upstream Bio stock, it's critical to research their stock before you buy, so you actually comprehend the risk and opportunity.

Upstream Bio quick stats

UPB Price
$22.28
1w %
12.58%
1y %
-5.71%
5y %
N/A
P/E
5.11x
P/B
2.94x
P/S
436.86x
PEG
N/A
Revenue
$2.72M
Earnings
-$110.06M
Fore. Rev. Growth
10.54%
Fore. Earn. Growth
N/A
Market Cap
$1.20B
Next Earnings
Nov 6, 2025
Next Dividend
N/A

Upstream Bio Due Diligence Score

WallStreetZen was built to help average investors do better fundamental analysis.

You can see all of the due diligence checks on UPB's stock page.

Is UPB stock overvalued?

You can use many financial metrics, analyses, models, and charts to gauge UPB's fair value.

Using relative valuations methods:

  • UPB could be undervalued based on its P/E ratio of 5.11x, relative to Biotechnology industry P/E ratio of -100.82x
  • UPB could be undervalued based on its P/B ratio of 2.94x, relative to Biotechnology industry P/B ratio of 4.99x

You can do additional valuation analysis on UPB's stock here.

UPB Financial Health

Passed Health Checks:

  • There are more short-term assets than long-term liabilities on the UPB balance sheet.
  • UPB has cash burn of 114536000. It has sufficient cash and short-term investments to cover this for at least one year.
  • UPB has a low debt to equity ratio of 0.03.
  • UPB has $393.78M in cash and short term investments. This is enough to cover its annual cash burn of $114.54M.
  • There are more short-term assets than short-term liabilities on the UPB balance sheet.

Failed Health Checks:

  • UPB profit margin has gone down from -2,467.8% to -4,041.8% in the past year.

Is it a good time to buy Upstream Bio stock, according to analysts?

Out of 1 Wall Street analysts who research UPB, the consensus analyst rating on Upstream Bio is a Strong Buy

Please keep in mind that analyst forecasts are not recommendations, nor are they investment advice.

You can dive deeper into what analysts are forecasting on the Upstream Bio stock forecast page.

Metrics for Advanced UPB Traders

SMA10
19.86
SMA20
18.58
SMA50
18.05
SMA100
14.88
SMA200
12.05
MACD
1.03
MACD Signal
0.68
MACD Histogram
0.36
RSI
73.78
Stochastic %K
93.23
Stochastic %D
88.66
StochRSI %K
98.28
StochRSI %D
97.36

UPB Growth Numbers

Last year, UPB revenue was $2.72M. Over the last 1 years, UPB's revenue has grown by 22.6% per year. This was slower than the Biotechnology industry average of 68.13%.

You can research UPB's earnings and revenue performance here.

Who is buying/selling UPB?

Over the last year, executives and large shareholders at UPB have not bought or sold any shares.

Dig into more about who owns UPB stock here.

Can I get consistent income from UPB stock?

No, Upstream Bio doesn't provide an income stream by paying out dividends.

What others are saying about UPB

One of the reasons eToro is our favorite brokerage is because of its social trading community.

Click below to learn what other traders have to say.

Step 5: Execute your UPB trade

There are two main options:

  • Market order: A market order is an order to buy or sell a security at the best available price.
    Market orders are usually the best for newer investors.
  • Limit order: A limit order enables you to buy or sell a stock at a specific price (or better).
    If you want to be certain you're buying or selling at a particular dollar amount limit, use a limit order.

Click the Open Trade button and your broker will place the order.

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Step 6: Keep an eye on your investment in UPB

Now that you own some UPB stock, you'll want to stay up-to-date on your investment.

Put UPB on a watchlist to track the latest developments regarding your UPB stock.

UPB Feed

How to Buy Stock in Upstream Bio

To summarize, here are the 6 steps for buying Upstream Bio stock:

  1. Figure out where to buy Upstream Bio stock
  2. Open a brokerage account
  3. Deposit funds into your investment account
  4. Research Upstream Bio stock
  5. Execute your UPB trade
  6. Keep an eye on your investment in UPB

If you need a brokerage account, eToro is our recommended option.

Get Started with eToro Today
eToro is a multi-asset investment platform. The value of your investments may go up or down. Your capital is at risk.

If you want to get the latest news on your investment in Upstream Bio, create a watchlist on WallStreetZen today.

NASDAQ: UPB
$22.28+0.59 (+2.72%)
Updated Oct 16, 2025
Open eToro Account
Your capital is at risk.
NASDAQ: UPB
$22.28+0.59 (+2.72%)
Updated Oct 16, 2025
Open eToro Account
Your capital is at risk.

FAQ

How much does it cost to buy one Upstream Bio share?

As of Oct 16, 2025, it costs $22.28 to buy one share of Upstream Bio stock.

Remember, eToro's fractional share buying allows you to buy partial shares of stocks and ETFs. Even if you only have $10, you can buy 0.449 shares of UPB.

Get Started with eToro Today
eToro is a multi-asset investment platform. The value of your investments may go up or down. Your capital is at risk.

Is now a good time to buy Upstream Bio stock?

According to 1 Wall Street analysts who monitor Upstream Bio, their consensus recommendation is to buy Upstream Bio stock.

What is the best way to buy Upstream Bio stock?

One way to place an order for Upstream Bio stock is with a brokerage account.
WallStreetZen does not provide financial advice and does not issue recommendations or offers to buy stock or sell any security.

Information is provided 'as-is' and solely for informational purposes and is not advice. WallStreetZen does not bear any responsibility for any losses or damage that may occur as a result of reliance on this data.