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NASDAQ: UPB
Upstream Bio Inc Stock Forecast, Predictions & Price Target

OverviewForecast
EarningsRevenueDividendOwnership

Analyst price target for UPB

Based on 3 analysts offering 12 month price targets for Upstream Bio Inc

Min Forecast
$40.00+172.29%
Avg Forecast
$46.00+213.14%
Max Forecast
$51.00+247.17%

Should I buy or sell UPB stock?

Based on 3 analysts offering ratings for Upstream Bio Inc.

Strong Buy
Strong Buy
1 analysts 33.33%
Buy
2 analysts 66.67%
Hold
0 analysts 0%
Sell
0 analysts 0%
Strong Sell
0 analysts 0%
Although UPB's forecast from analysts indicates a "Strong Buy", our proven Zen Rating quant model rates UPB as a "Hold". Stocks with a Zen Rating of Hold have had an average return of +7.53% per year. Learn More

Be the first to know when Wall Street analysts revise their UPB stock forecasts and price targets.

UPB stock forecasts by analyst

Analyst / FirmRatingActionPrice TargetUpside/DownsideDateAnalyst Color
lockedlocked$00.00+00.00%2025-12-18
lockedlocked$00.00+00.00%2025-12-02
lockedlocked$00.00+00.00%2025-11-18
lockedlocked$00.00+00.00%2025-10-14

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Forecast return on equity

Is UPB forecast to generate an efficient return?

Company
-55%
Industry
310.8%
Market
238.59%
UPB's Return on Equity is... subscribe to Premium to read more.
Forecast High Return on Equity Forecast

Forecast return on assets

Is UPB forecast to generate an efficient return on assets?

Company
-53.23%
Industry
115.15%
UPB is forecast to generate... subscribe to Premium to read more.
Forecast Return on Assets vs Industry Forecast

UPB earnings per share forecast

What is UPB's earnings per share in the next 3 years based on estimates from 8 analysts?

Avg 1 year Forecast
-$3.18-129.71%
Avg 2 year Forecast
-$3.66-134.26%
Avg 3 year Forecast
-$5.25-149.1%

UPB revenue forecast

What is UPB's revenue in the next 3 years based on estimates from 8 analysts?

Avg 1 year Forecast
$1.6M-44.62%
Avg 2 year Forecast
$1.6M-41.44%
Avg 3 year Forecast
$5.7M+103.82%
UPB's revenue is forecast to... subscribe to Premium to read more.
Forecast High Revenue Growth Forecast

UPB revenue growth forecast

How is UPB forecast to perform vs Biotechnology companies and vs the US market?

Company
19.28%
Industry
118.19%
Market
23.42%
UPB's revenues are forecast to... subscribe to Premium to read more.
Forecast Revenue Growth vs Industry Forecast
UPB's revenues are forecast to... subscribe to Premium to read more.
Forecast Revenue Growth vs Market Forecast

UPB vs Biotech Stocks

TickerPricePrice TargetUp/downsideConsensus
UPB$14.69$46.00+213.14%Strong Buy
OMER$11.23$40.33+259.15%Strong Buy
MRVI$3.12$4.83+54.90%Strong Buy
JANX$13.11$56.63+331.92%Strong Buy
ABUS$4.16$5.00+20.19%Strong Buy
View Top Biotech Stocks

Upstream Bio Stock Forecast FAQ

Is Upstream Bio Stock a good buy in 2026, according to Wall Street analysts?

The consensus among 3 Wall Street analysts covering (NASDAQ: UPB) stock is to Strong Buy UPB stock.

Out of 3 analysts, 1 (33.33%) are recommending UPB as a Strong Buy, 2 (66.67%) are recommending UPB as a Buy, 0 (0%) are recommending UPB as a Hold, 0 (0%) are recommending UPB as a Sell, and 0 (0%) are recommending UPB as a Strong Sell.

If you're new to stock investing, here's how to buy Upstream Bio stock.

What is UPB's earnings growth forecast for 2026-2028?

(NASDAQ: UPB) Upstream Bio's forecast annual earnings growth rate of N/A is not forecast to beat the US Biotechnology industry's average forecast earnings growth rate of 68.99%, and while it is not forecast to beat the US market's average forecast earnings growth rate of 39.82%.

Upstream Bio's earnings in 2026 is -$122,774,000.On average, 8 Wall Street analysts forecast UPB's earnings for 2026 to be -$171,653,584, with the lowest UPB earnings forecast at -$204,417,182, and the highest UPB earnings forecast at -$146,390,543. On average, 6 Wall Street analysts forecast UPB's earnings for 2027 to be -$197,905,532, with the lowest UPB earnings forecast at -$282,265,176, and the highest UPB earnings forecast at -$135,042,439.

In 2028, UPB is forecast to generate -$283,632,353 in earnings, with the lowest earnings forecast at -$462,851,340 and the highest earnings forecast at -$141,283,896.

What is UPB's revenue growth forecast for 2026-2028?

(NASDAQ: UPB) Upstream Bio's forecast annual revenue growth rate of 19.28% is not forecast to beat the US Biotechnology industry's average forecast revenue growth rate of 118.19%, and while it is not forecast to beat the US market's average forecast revenue growth rate of 23.42%.

Upstream Bio's revenue in 2026 is $2,799,000.On average, 8 Wall Street analysts forecast UPB's revenue for 2026 to be $83,759,816, with the lowest UPB revenue forecast at $0, and the highest UPB revenue forecast at $198,591,822. On average, 6 Wall Street analysts forecast UPB's revenue for 2027 to be $88,569,251, with the lowest UPB revenue forecast at $0, and the highest UPB revenue forecast at $198,591,822.

In 2028, UPB is forecast to generate $308,290,162 in revenue, with the lowest revenue forecast at $0 and the highest revenue forecast at $785,072,650.

What is UPB's forecast return on assets (ROA) for 2026-2029?

(NASDAQ: UPB) forecast ROA is -53.23%, which is lower than the forecast US Biotechnology industry average of 115.15%.

What is UPB's Price Target?

According to 3 Wall Street analysts that have issued a 1 year UPB price target, the average UPB price target is $46.00, with the highest UPB stock price forecast at $51.00 and the lowest UPB stock price forecast at $40.00.

On average, Wall Street analysts predict that Upstream Bio's share price could reach $46.00 by Dec 18, 2026. The average Upstream Bio stock price prediction forecasts a potential upside of 213.14% from the current UPB share price of $14.69.

What is UPB's Earnings Per Share (EPS) forecast for 2026-2028?

(NASDAQ: UPB) Upstream Bio's current Earnings Per Share (EPS) is $10.69. On average, analysts forecast that UPB's EPS will be -$3.18 for 2026, with the lowest EPS forecast at -$3.78, and the highest EPS forecast at -$2.71. On average, analysts forecast that UPB's EPS will be -$3.66 for 2027, with the lowest EPS forecast at -$5.22, and the highest EPS forecast at -$2.50. In 2028, UPB's EPS is forecast to hit -$5.25 (min: -$8.57, max: -$2.61).

What is UPB's forecast return on equity (ROE) for 2026-2029?

(NASDAQ: UPB) forecast ROE is -55%, which is considered weak.
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