NASDAQ: UPB
Upstream Bio Inc Stock Ownership - Who owns Upstream Bio?

Insider buying vs selling

Have Upstream Bio Inc insiders been buying or selling?

Buy
Sell
NameRoleDateSharesPriceValue
Allison AmbroseGeneral Counsel2026-03-16475$9.29
$4.41kSell
Aaron DeykinChief Medical Officer2026-03-16894$9.29
$8.31kSell
Michael GrayCFO and COO2026-03-16852$9.29
$7.92kSell
Adam HoughtonChief Business Officer2026-03-16699$9.29
$6.49kSell
Everett Rand SutherlandChief Executive Officer2026-03-162,093$9.29
$19.44kSell

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Net Insider Buy/Sell (L12M) Ownership

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UPB Shareholders

What type of owners hold Upstream Bio Inc stock?

Institutional
Insider
Retail
NameHoldSharesValueType
Fmr LLC14.89%8,101,563$49.42MInstitution
Orbimed Advisors LLC10.68%5,813,673$35.46MInsider
Erez Chimovits10.68%5,813,673$35.46MInsider
Orbimed Advisors LLC10.46%5,693,589$34.73MInstitution
Ai Upstream LLC10.10%5,494,410$33.52MInsider
Blackrock Inc6.19%3,370,689$20.56MInstitution
Decheng Capital LLC5.01%2,724,868$16.62MInstitution
Enavate Sciences GP LLC4.52%2,459,703$15.00MInstitution
Vanguard Capital Management LLC3.44%1,873,574$11.43MInstitution
Yintercept Hong Kong Ltd1.84%1,000,631$6.10MInstitution

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UPB vs Biotech Stocks

TickerInst. %Insider %Net Insider (L12M)Net Insider (L3M)
UPB71.16%28.84%Net SellingNet Selling
NMRA30.07%69.93%Net Buying
OABI38.59%22.92%Net BuyingNet Selling
IRD12.84%87.16%Net SellingNet Selling
LXEO91.46%8.54%Net SellingNet Selling

Upstream Bio Stock Ownership FAQ

Who owns Upstream Bio?

Upstream Bio (NASDAQ: UPB) is owned by 82.48% institutional shareholders, 33.43% Upstream Bio insiders, and 0.00% retail investors. Orbimed Advisors LLC is the largest individual Upstream Bio shareholder, owning 5.81M shares representing 10.68% of the company. Orbimed Advisors LLC's Upstream Bio shares are currently valued at $35.46M.

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