| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Eugene Schneider | EVP Chf Clinical Develop Ofcr | 2026-03-19 | 5,812 | $70.97 | $412.49kSell |
| Elizabeth L. Hougen | EVP Finance CFO | 2026-03-17 | 10,172 | $73.21 | $744.66kSell |
| Elizabeth L. Hougen | EVP Finance CFO | 2026-03-16 | 61,041 | $56.78 | $3.47MBuy |
| Elizabeth L. Hougen | EVP Finance CFO | 2026-03-16 | 60,299 | $60.89 | $3.67MBuy |
| Elizabeth L. Hougen | EVP Finance CFO | 2026-03-16 | 33,118 | $32.60 | $1.08MBuy |
| Elizabeth L. Hougen | EVP Finance CFO | 2026-03-16 | 20,541 | $37.58 | $771.93kBuy |
| Elizabeth L. Hougen | EVP Finance CFO | 2026-03-16 | 205,608 | $72.38 | $14.88MSell |
| Elizabeth L. Hougen | EVP Finance CFO | 2026-03-16 | 9,440 | $72.77 | $686.90kSell |
| Brett P. Monia | Chief Executive Officer | 2026-03-10 | 17,591 | $76.34 | $1.34MSell |
| Brett P. Monia | Chief Executive Officer | 2026-03-10 | 34,103 | $60.89 | $2.08MBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Fmr LLC | 14.57% | 24,072,101 | $1.74B | Institution |
| Capital World Investors | 10.87% | 17,961,299 | $1.30B | Institution |
| Vanguard Group Inc | 9.95% | 16,440,459 | $1.19B | Institution |
| Blackrock Inc | 6.45% | 10,647,863 | $768.24M | Institution |
| T Rowe Price Investment Management Inc | 5.51% | 9,108,019 | $657.14M | Institution |
| Wellington Management Group LLP | 3.79% | 6,260,325 | $451.68M | Institution |
| Bellevue Group Ag | 2.91% | 4,802,199 | $346.48M | Institution |
| State Street Corp | 2.41% | 3,974,865 | $286.79M | Institution |
| Geode Capital Management LLC | 1.91% | 3,148,849 | $227.19M | Institution |
| Two Sigma Advisers LP | 1.85% | 3,052,111 | $220.21M | Institution |