| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| William John Sibold | President and CEO | 2025-09-09 | 7,279 | $445.63 | $3.24MSell |
| William John Sibold | President and CEO | 2025-08-21 | 6,485 | $400.04 | $2.59MSell |
| William John Sibold | President and CEO | 2025-08-21 | 1,131 | $401.00 | $453.53kSell |
| Baker Bros Advisors LP | Director | 2025-08-20 | 4,049 | $383.79 | $1.55MBuy |
| Baker Bros Advisors LP | Director | 2025-08-20 | 1,248 | $385.06 | $480.55kBuy |
| Baker Bros Advisors LP | Director | 2025-08-20 | 13,545 | $385.06 | $5.22MBuy |
| Baker Bros Advisors LP | Director | 2025-08-20 | 409 | $387.07 | $158.31kBuy |
| Baker Bros Advisors LP | Director | 2025-08-20 | 4,441 | $387.07 | $1.72MBuy |
| Baker Bros Advisors LP | Director | 2025-08-20 | 34 | $389.00 | $13.23kBuy |
| Baker Bros Advisors LP | Director | 2025-08-20 | 366 | $389.00 | $142.37kBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Bruce Kovner | 102.91% | 22,937,805 | $9.72B | Insider |
| Cxsynta LLC | 34.82% | 7,761,716 | $3.29B | Insider |
| Lan Bo Chen | 27.56% | 6,142,288 | $2.60B | Insider |
| Fred B. Craves | 27.10% | 6,040,140 | $2.56B | Insider |
| Lin Huey Chen | 26.88% | 5,991,757 | $2.54B | Insider |
| Bay City Capital LLC | 25.79% | 5,747,267 | $2.44B | Insider |
| Safi R. Bahcall | 12.65% | 2,818,885 | $1.19B | Insider |
| Keith R. Gollust | 10.28% | 2,290,933 | $971.06M | Insider |
| Janus Henderson Group PLC | 9.83% | 2,191,753 | $929.02M | Institution |
| Paulson Co Inc | 9.37% | 2,089,523 | $885.69M | Institution |