NASDAQ: KPTIKaryopharm Therapeutics Inc Stock
$6.02-0.31 (-4.9%)
Updated Dec 17, 2025
KPTI Price
$6.02
Fair Value Price
N/A
Market Cap
$102.65M
52 Week Low
$3.51
52 Week High
$12.45
P/E
-0.41x
P/B
-0.38x
P/S
0.4x
PEG
N/A
Dividend Yield
N/A
Revenue
$142.53M
Earnings
-$124.62M
Gross Margin
95.9%
Operating Margin
-56.26%
Profit Margin
-87.4%
Debt to Equity
-1.36
Operating Cash Flow
-$89M
Beta
1.26
Next Earnings
N/A
Ex-Dividend
N/A
Next Dividend
N/A
KPTI Overview
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma, and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. The company has license agreement with Menarini Group to develop and commercialize NEXPOVIO for human oncology indications in Europe, including the United Kingdom; Latin America; and other countries. Its oral SINE compounds also designed to force nuclear accumulation in the levels of multiple tumor suppressor and growth regulatory proteins. The company was incorporated in 2008 and is headquartered in Newton, Massachusetts.
Zen Rating
Our proven quant model uses 115 proprietary factors, including AI, to determine KPTI's potential to beat the market
CHold
- Stocks with a Zen Rating of Hold (C) had an average return of +7.53% per year. Learn More
Zen Rating Component Grades
D
Zen Rating uses advanced AI algorithms that detect subtle patterns in market data; it anticipates future trends that point to superior stock price results.
Industry: Biotech
Industry Rating
F
KPTI
Ranked#209 of 488
Ranked#209 of 488
Top Ranked Stocks in Industry
| Name / Ticker | Price | Zen Rating |
|---|---|---|
| $20.05 | A | |
| $306.05 | A | |
| $7.13 | A |
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KPTI News
Overview
Due Diligence Score
–
Industry Average (23)
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Due Diligence Checks
KPTI is unprofitable, so we are unable to calculate its intrinsic value according to an updated version of Benjamin Graham's Formula from "The Intelligent Investor"
Below Benjamin Graham Formula Value Valuation
KPTI is unprofitable, so we are unable to assess its PEG ratio
PEG Value Valuation
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Interest Coverage Financials
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Valuation
KPTI price to earnings (PE)
For valuing profitable companies with steady earnings
Company
-0.41x
Industry
152.67x
Market
43.93x
KPTI price to book (PB)
For valuing companies that are loss-making or have lots of physical asset
Company
-0.38x
Industry
5.19x
KPTI's financial health
Profit margin
Revenue
$44.0M
Net Income
-$33.1M
Profit Margin
-75.2%
KPTI's cash and short-term investments... subscribe to Premium to read more.
Interest Coverage Financials
KPTI's profit margin has decreased... subscribe to Premium to read more.
Profit Margin Growth Financials
Assets to liabilities
Assets
$96.2M
Liabilities
$365.5M
Debt to equity
-1.36
KPTI's short-term assets ($89.75M) exceed... subscribe to Premium to read more.
Short-term Liabilities Financials
KPTI's long-term liabilities ($278.33M) exceed... subscribe to Premium to read more.
Long-term Liabilities Financials
KPTI's debt relative to shareholder... subscribe to Premium to read more.
Shrinking Debt Financials
KPTI's debt to equity ratio... subscribe to Premium to read more.
Healthy Debt to Equity Financials
Cash flow
Operating
-$5.9M
Investing
$4.8M
Financing
$0.0
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Debt Coverage Financials
KPTI vs Biotech Stocks
Karyopharm Therapeutics Stock FAQ
Company
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Information is provided 'as-is' and solely for informational purposes and is not advice. WallStreetZen does not bear any responsibility for any losses or damage that may occur as a result of reliance on this data.