| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Orbis Allan Gray Ltd | 17.25% | 11,078,006 | $338.99M | Institution |
| Alliancebernstein LP | 17.06% | 10,953,913 | $335.19M | Institution |
| Paradigm Biocapital Advisors LP | 5.94% | 3,816,851 | $116.80M | Institution |
| Arrowstreet Capital Limited Partnership | 5.67% | 3,643,139 | $111.48M | Institution |
| Harding Loevner LP | 5.43% | 3,484,487 | $106.63M | Institution |
| Blackrock Inc | 5.37% | 3,450,526 | $105.59M | Institution |
| Renaissance Technologies LLC | 4.39% | 2,821,543 | $86.34M | Institution |
| First Trust Advisors LP | 2.63% | 1,687,388 | $51.63M | Institution |
| Morgan Stanley | 2.61% | 1,674,574 | $51.24M | Institution |
| Two Sigma Advisers LP | 2.23% | 1,432,800 | $43.84M | Institution |