| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Orbis Allan Gray Ltd | 17.25% | 11,078,006 | $357.82M | Institution |
| Alliancebernstein LP | 17.06% | 10,953,913 | $353.81M | Institution |
| Paradigm Biocapital Advisors LP | 5.94% | 3,816,851 | $123.28M | Institution |
| Arrowstreet Capital Limited Partnership | 5.67% | 3,643,139 | $117.67M | Institution |
| Harding Loevner LP | 5.43% | 3,484,487 | $112.55M | Institution |
| Blackrock Inc | 5.37% | 3,450,526 | $111.45M | Institution |
| Renaissance Technologies LLC | 4.39% | 2,821,543 | $91.14M | Institution |
| First Trust Advisors LP | 2.63% | 1,687,388 | $54.50M | Institution |
| Morgan Stanley | 2.61% | 1,674,574 | $54.09M | Institution |
| Two Sigma Advisers LP | 2.23% | 1,432,800 | $46.28M | Institution |