| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Mark A. Goldsmith | President and Chief Executive Officer | 2026-04-15 | 120,000 | $150.09 | $18.01MSell |
| Mark A. Goldsmith | President and Chief Executive Officer | 2026-04-15 | 23,244 | $4.09 | $95.07kBuy |
| Mark A. Goldsmith | President and Chief Executive Officer | 2026-04-15 | 96,756 | $4.73 | $457.66kBuy |
| Anthony Mancini | Chief Global Commercialization Officer | 2026-03-25 | 1,800 | $93.22 | $167.80kSell |
| Anthony Mancini | Chief Global Commercialization Officer | 2026-03-25 | 37,450 | $33.62 | $1.26MBuy |
| Anthony Mancini | Chief Global Commercialization Officer | 2026-03-25 | 400 | $97.21 | $38.88kSell |
| Anthony Mancini | Chief Global Commercialization Officer | 2026-03-25 | 21,086 | $95.49 | $2.01MSell |
| Anthony Mancini | Chief Global Commercialization Officer | 2026-03-25 | 3,128 | $94.16 | $294.52kSell |
| Anthony Mancini | Chief Global Commercialization Officer | 2026-03-25 | 11,036 | $96.43 | $1.06MSell |
| Jeff Cislini | General Counsel | 2026-03-19 | 1,163 | $97.44 | $113.32kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Vanguard Group Inc | 8.44% | 16,719,886 | $2.26B | Institution |
| Farallon Capital Management LLC | 7.36% | 14,582,796 | $1.97B | Institution |
| Janus Henderson Group PLC | 6.21% | 12,303,502 | $1.66B | Institution |
| Baker Bros Advisors LP | 4.77% | 9,455,357 | $1.28B | Institution |
| Blackrock Inc | 4.50% | 8,926,656 | $1.21B | Institution |
| Fmr LLC | 4.33% | 8,587,981 | $1.16B | Institution |
| Thilo Schroeder | 4.08% | 8,085,752 | $1.09B | Insider |
| Nextech Invest Ltd | 3.84% | 7,601,087 | $1.03B | Institution |
| Wellington Management Group LLP | 3.53% | 6,987,639 | $945.43M | Institution |
| Paradigm Biocapital Advisors LP | 3.35% | 6,644,403 | $898.99M | Institution |