| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 23,594 | $29.80 | $703.10kBuy |
| Jack Anders | Chief Financial Officer | 2026-01-07 | 10,000 | $98.00 | $980.00kSell |
| Jack Anders | Chief Financial Officer | 2026-01-07 | 10,000 | $42.45 | $424.50kBuy |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 51,406 | $42.45 | $2.18MBuy |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 1,700 | $102.90 | $174.93kSell |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 20,204 | $101.79 | $2.06MSell |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 53,096 | $100.02 | $5.31MSell |
| Mark A. Goldsmith | President and Chief Executive Officer | 2025-12-16 | 15,394 | $76.82 | $1.18MSell |
| Jeff Cislini | General Counsel | 2025-12-16 | 2,688 | $76.82 | $206.48kSell |
| Stephen Michael Kelsey | President Research and Development | 2025-12-16 | 5,447 | $76.82 | $418.42kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Vanguard Group Inc | 8.10% | 15,663,094 | $1.86B | Institution |
| Farallon Capital Management LLC | 7.57% | 14,625,692 | $1.74B | Institution |
| Janus Henderson Group PLC | 5.87% | 11,356,054 | $1.35B | Institution |
| Wellington Management Group LLP | 5.08% | 9,813,436 | $1.16B | Institution |
| Baker Bros Advisors LP | 4.89% | 9,455,357 | $1.12B | Institution |
| Fmr LLC | 4.86% | 9,401,687 | $1.12B | Institution |
| Blackrock Inc | 4.31% | 8,327,758 | $988.01M | Institution |
| Thilo Schroeder | 4.18% | 8,085,752 | $959.29M | Insider |
| Nextech Invest Ltd | 3.93% | 7,601,087 | $901.79M | Institution |
| Paradigm Biocapital Advisors LP | 3.22% | 6,223,291 | $738.33M | Institution |