| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Mark A. Goldsmith | President and Chief Executive Officer | 2026-02-06 | 24,010 | $0.54 | $12.97kBuy |
| Jeff Cislini | General Counsel | 2026-01-21 | 908 | $115.60 | $104.96kSell |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 51,406 | $42.45 | $2.18MBuy |
| Jack Anders | Chief Financial Officer | 2026-01-07 | 10,000 | $42.45 | $424.50kBuy |
| Jack Anders | Chief Financial Officer | 2026-01-07 | 10,000 | $98.00 | $980.00kSell |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 53,096 | $100.02 | $5.31MSell |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 23,594 | $29.80 | $703.10kBuy |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 1,700 | $102.90 | $174.93kSell |
| Margaret A. Horn | Chief Operating Officer | 2026-01-07 | 20,204 | $101.79 | $2.06MSell |
| Jeff Cislini | General Counsel | 2025-12-16 | 2,688 | $76.82 | $206.48kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Vanguard Group Inc | 8.44% | 16,719,886 | $1.70B | Institution |
| Farallon Capital Management LLC | 7.36% | 14,582,796 | $1.48B | Institution |
| Janus Henderson Group PLC | 6.21% | 12,303,502 | $1.25B | Institution |
| Baker Bros Advisors LP | 4.77% | 9,455,357 | $960.85M | Institution |
| Blackrock Inc | 4.50% | 8,926,656 | $907.13M | Institution |
| Fmr LLC | 4.33% | 8,587,981 | $872.71M | Institution |
| Thilo Schroeder | 4.08% | 8,085,752 | $821.67M | Insider |
| Nextech Invest Ltd | 3.84% | 7,601,087 | $772.42M | Institution |
| Wellington Management Group LLP | 3.53% | 6,987,639 | $710.08M | Institution |
| Paradigm Biocapital Advisors LP | 3.35% | 6,644,403 | $675.20M | Institution |