| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Mark A. Goldsmith | President and Chief Executive Officer | 2025-11-25 | 60,000 | $4.09 | $245.40kBuy |
| Jack Anders | Chief Financial Officer | 2025-11-25 | 5,418 | $74.00 | $400.93kSell |
| Jack Anders | Chief Financial Officer | 2025-11-25 | 5,418 | $17.00 | $92.11kBuy |
| Mark A. Goldsmith | President and Chief Executive Officer | 2025-11-25 | 3,000 | $75.00 | $225.00kSell |
| Mark A. Goldsmith | President and Chief Executive Officer | 2025-11-25 | 3,000 | $75.00 | $225.00kSell |
| Mark A. Goldsmith | President and Chief Executive Officer | 2025-11-25 | 60,000 | $75.08 | $4.50MSell |
| Jeff Cislini | General Counsel | 2025-11-18 | 13,388 | $70.14 | $939.01kSell |
| Mark A. Goldsmith | President and Chief Executive Officer | 2025-11-18 | 20,000 | $70.38 | $1.41MSell |
| Mark A. Goldsmith | President and Chief Executive Officer | 2025-11-18 | 20,000 | $4.09 | $81.80kBuy |
| Jeff Cislini | General Counsel | 2025-11-18 | 13,388 | $42.45 | $568.32kBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Vanguard Group Inc | 8.10% | 15,663,094 | $1.19B | Institution |
| Farallon Capital Management LLC | 7.57% | 14,625,692 | $1.11B | Institution |
| Janus Henderson Group PLC | 5.87% | 11,356,054 | $860.79M | Institution |
| Wellington Management Group LLP | 5.08% | 9,813,436 | $743.86M | Institution |
| Baker Bros Advisors LP | 4.89% | 9,455,357 | $716.72M | Institution |
| Fmr LLC | 4.86% | 9,401,687 | $712.65M | Institution |
| Blackrock Inc | 4.31% | 8,327,758 | $631.24M | Institution |
| Thilo Schroeder | 4.18% | 8,085,752 | $612.90M | Insider |
| Nextech Invest Ltd | 3.93% | 7,601,087 | $576.16M | Institution |
| Paradigm Biocapital Advisors LP | 3.22% | 6,223,291 | $471.73M | Institution |