Penumbra, Inc. manufactures medical devices in the U.S. and internationally. Offerings include aspiration-based thrombectomy systems and accessory devices under the Penumbra RED, JET, ACE, 3D Revascularization Device, and Penumbra ENGINE brands, and neurovascular embolization coiling systems to treat patients with various sizes of aneurysms and other neurovascular lesions under the Penumbra Coil 400, POD400, PAC400, and Penumbra SMART Coil brand names. Penumbra was incorporated in 2004 and is headquartered in Alameda, CA.