NASDAQ: SLN
Silence Therapeutics PLC Stock

$4.81-0.29 (-5.69%)
Updated Aug 29, 2025
SLN Price
$4.81
Fair Value Price
N/A
Market Cap
$226.97M
52 Week Low
$1.97
52 Week High
$20.48
P/E
N/A
P/B
-2.41x
P/S
10.01x
PEG
N/A
Dividend Yield
N/A
Revenue
$27.37M
Earnings
-$79.40M
Gross Margin
78.5%
Operating Margin
-271.7%
Profit Margin
-290.1%
Debt to Equity
-0.76
Operating Cash Flow
-$86M
Beta
0.59
Next Earnings
N/A
Ex-Dividend
N/A
Next Dividend
N/A

SLN Overview

Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver. It designs short interfering RNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.

Zen Rating

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C
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Industry: Biotech

Industry Rating
F
SLN
Ranked
#289 of 482

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SLN News

Overview

Due Diligence Score

Industry Average (23)
You've viewed Due Diligence Score for 10/10 free stocks. Upgrade to Premium to see how SLN scored across 33 valuation, financial, forecast, performance, and dividend due diligence checks.

Due Diligence Checks

SLN's cash and short-term investments ($114.16M) cannot cover SLN's cash burn for the next year ($179.81M), once increasing cash burn (107.81%) is accounted for
Interest Coverage Financials
SLN's profit margin has decreased (-65.5%) in the last year from (-224.6%) to (-290.1%)
Profit Margin Growth Financials
SLN's short-term assets ($148.55M) exceed... subscribe to Premium to read more.
Short-term Liabilities Financials
There are 30 more SLN due diligence checks available for Premium users.

Valuation

SLN price to earnings (PE)

For valuing profitable companies with steady earnings

Company
0x
Industry
-102.1x
Market
35.25x

SLN price to book (PB)

For valuing companies that are loss-making or have lots of physical asset

Company
-2.41x
Industry
4.56x

SLN's financial health

Profit margin

Revenue
$224.0k
Net Income
-$27.4M
Profit Margin
-12,211.6%
SLN's cash and short-term investments... subscribe to Premium to read more.
Interest Coverage Financials
SLN's profit margin has decreased... subscribe to Premium to read more.
Profit Margin Growth Financials

Assets to liabilities

Assets
$165.2M
Liabilities
$71.1M
Debt to equity
-0.76
SLN's short-term assets ($148.55M) exceed... subscribe to Premium to read more.
Short-term Liabilities Financials
SLN's short-term assets ($148.55M) exceed... subscribe to Premium to read more.
Long-term Liabilities Financials
SLN's debt relative to shareholder... subscribe to Premium to read more.
Shrinking Debt Financials
SLN's debt to equity ratio... subscribe to Premium to read more.
Healthy Debt to Equity Financials

Cash flow

Operating
-$21.8M
Investing
-$1.6M
Financing
$1.0k
SLN's cash and short-term investments... subscribe to Premium to read more.
Debt Coverage Financials

SLN vs Biotech Stocks

TickerZen RatingMarket Cap1d %P/EP/B
SLND$226.97M-5.69%N/A-2.41x
QSIF$226.79M-2.61%-1.65x1.03x
ANNXD$226.37M-2.83%-1.60x1.14x
EDITD$231.09M-3.02%-0.90x12.04x
IMMP$234.35M-3.01%-7.74x2.16x

Silence Therapeutics Stock FAQ

What is Silence Therapeutics's quote symbol?

(NASDAQ: SLN) Silence Therapeutics trades on the NASDAQ under the ticker symbol SLN. Silence Therapeutics stock quotes can also be displayed as NASDAQ: SLN.

If you're new to stock investing, here's how to buy Silence Therapeutics stock.

What is the 52 week high and low for Silence Therapeutics (NASDAQ: SLN)?

(NASDAQ: SLN) Silence Therapeutics's 52-week high was $20.48, and its 52-week low was $1.97. It is currently -76.51% from its 52-week high and 144.16% from its 52-week low.

How much is Silence Therapeutics stock worth today?

(NASDAQ: SLN) Silence Therapeutics currently has 141,701,848 outstanding shares. With Silence Therapeutics stock trading at $4.81 per share, the total value of Silence Therapeutics stock (market capitalization) is $226.97M.

Silence Therapeutics stock was originally listed at a price of $19.50 in Sep 8, 2020. If you had invested in Silence Therapeutics stock at $19.50, your return over the last 4 years would have been -75.33%, for an annualized return of -29.53% (not including any dividends or dividend reinvestments).

How much is Silence Therapeutics's stock price per share?

(NASDAQ: SLN) Silence Therapeutics stock price per share is $4.81 today (as of Aug 29, 2025).

What is Silence Therapeutics's Market Cap?

(NASDAQ: SLN) Silence Therapeutics's market cap is $226.97M, as of Aug 30, 2025.

Market cap (market capitalization) is the total market value of a publicly traded company's outstanding shares.

Silence Therapeutics's market cap is calculated by multiplying SLN's current stock price of $4.81 by SLN's total outstanding shares of 141,701,848.
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