| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Deborah Ann Miller | Chief Legal Officer | 2026-04-30 | 5,500 | $6.89 | $37.90kBuy |
| Deborah Ann Miller | Chief Legal Officer | 2026-04-30 | 1,082 | $99.57 | $107.73kSell |
| Deborah Ann Miller | Chief Legal Officer | 2026-04-30 | 4,418 | $99.13 | $437.96kSell |
| Darlene Noci | Chief Development Officer | 2026-04-29 | 700 | $100.14 | $70.10kSell |
| Darlene Noci | Chief Development Officer | 2026-04-29 | 300 | $101.17 | $30.35kSell |
| Darlene Noci | Chief Development Officer | 2026-04-29 | 5,500 | $27.85 | $153.18kBuy |
| Darlene Noci | Chief Development Officer | 2026-04-29 | 4,500 | $99.35 | $447.08kSell |
| Henry E. Pelish | Chief Scientific Officer | 2026-04-09 | 900 | $105.00 | $94.50kSell |
| Henry E. Pelish | Chief Scientific Officer | 2026-04-09 | 2,193 | $104.27 | $228.66kSell |
| Henry E. Pelish | Chief Scientific Officer | 2026-04-09 | 3,093 | $27.85 | $86.14kBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| James E. Flynn | 22.77% | 17,903,448 | $1.77B | Insider |
| Deerfield Management Company LP | 21.94% | 17,248,450 | $1.71B | Institution |
| Fmr LLC | 13.80% | 10,852,884 | $1.07B | Institution |
| Paradigm Biocapital Advisors LP | 6.70% | 5,269,433 | $521.88M | Institution |
| Vanguard Group Inc | 6.67% | 5,244,271 | $519.39M | Institution |
| Blackrock Inc | 6.11% | 4,805,261 | $475.91M | Institution |
| Wellington Management Group LLP | 3.13% | 2,461,823 | $243.82M | Institution |
| Jpmorgan Chase Co | 2.81% | 2,205,251 | $218.41M | Institution |
| Price T Rowe Associates Inc | 2.73% | 2,146,938 | $212.63M | Institution |
| Ra Capital Management LP | 2.39% | 1,880,057 | $186.20M | Institution |