| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Deborah Ann Miller | Chief Legal Officer | 2026-01-22 | 14,300 | $110.16 | $1.58MSell |
| Deborah Ann Miller | Chief Legal Officer | 2026-01-22 | 14,300 | $27.85 | $398.26kBuy |
| Deborah Ann Miller | Chief Legal Officer | 2026-01-21 | 700 | $27.85 | $19.50kBuy |
| Deborah Ann Miller | Chief Legal Officer | 2026-01-21 | 700 | $109.84 | $76.89kSell |
| Christopher Durant Turner | Chief Medical Officer | 2026-01-06 | 1,635 | $97.33 | $159.13kSell |
| Darlene Noci | Chief Development Officer | 2026-01-06 | 1,321 | $96.75 | $127.81kSell |
| Darlene Noci | Chief Development Officer | 2026-01-06 | 1,635 | $97.33 | $159.13kSell |
| Darlene Noci | Chief Development Officer | 2026-01-06 | 225 | $98.40 | $22.14kSell |
| James Richard Porter | President and CEO | 2026-01-06 | 675 | $98.40 | $66.42kSell |
| James Richard Porter | President and CEO | 2026-01-06 | 4,905 | $97.33 | $477.40kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Deerfield Management Company LP | 24.74% | 17,991,024 | $1.85B | Institution |
| James E. Flynn | 24.62% | 17,903,448 | $1.84B | Insider |
| Fmr LLC | 13.77% | 10,013,237 | $1.03B | Institution |
| Paradigm Biocapital Advisors LP | 7.25% | 5,269,433 | $542.17M | Institution |
| Vanguard Group Inc | 6.33% | 4,605,007 | $473.81M | Institution |
| Blackrock Inc | 5.62% | 4,085,795 | $420.39M | Institution |
| Wellington Management Group LLP | 3.16% | 2,300,865 | $236.74M | Institution |
| Janus Henderson Group PLC | 3.01% | 2,188,674 | $225.19M | Institution |
| Price T Rowe Associates Inc | 2.49% | 1,810,420 | $186.27M | Institution |
| Jpmorgan Chase Co | 2.30% | 1,674,009 | $172.24M | Institution |