| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Darlene Noci | Chief Development Officer | 2025-10-30 | 4,000 | $27.85 | $111.40kBuy |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 600 | $100.96 | $60.58kSell |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 500 | $99.66 | $49.83kSell |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 1,273 | $97.98 | $124.73kSell |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 700 | $96.65 | $67.66kSell |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 21,800 | $6.89 | $150.20kBuy |
| Darlene Noci | Chief Development Officer | 2025-10-30 | 57 | $98.91 | $5.64kSell |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 9,382 | $104.78 | $983.05kSell |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 3,491 | $103.90 | $362.71kSell |
| Deborah Ann Miller | Chief Legal Officer | 2025-10-30 | 2,121 | $102.00 | $216.34kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| James E. Flynn | 25.86% | 18,646,022 | $1.83B | Insider |
| Deerfield Management Company LP | 24.95% | 17,991,024 | $1.77B | Institution |
| Fmr LLC | 13.83% | 9,968,846 | $978.64M | Institution |
| Paradigm Biocapital Advisors LP | 7.31% | 5,269,433 | $517.30M | Institution |
| Vanguard Group Inc | 6.27% | 4,524,124 | $444.13M | Institution |
| Blackrock Inc | 5.61% | 4,046,256 | $397.22M | Institution |
| Price T Rowe Associates Inc | 2.49% | 1,795,373 | $176.25M | Institution |
| Janus Henderson Group PLC | 2.47% | 1,782,581 | $175.00M | Institution |
| Matthew Shair | 2.20% | 1,586,366 | $155.73M | Insider |
| Wellington Management Group LLP | 2.19% | 1,576,374 | $154.75M | Institution |