| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Darlene Noci | Chief Development Officer | 2026-06-09 | 685 | $6.89 | $4.72kBuy |
| Darlene Noci | Chief Development Officer | 2026-06-09 | 10,000 | $1.08 | $10.80kBuy |
| Darlene Noci | Chief Development Officer | 2026-06-09 | 20,000 | $122.81 | $2.46MSell |
| Darlene Noci | Chief Development Officer | 2026-06-09 | 9,315 | $18.93 | $176.33kBuy |
| James Richard Porter | President and CEO | 2026-06-08 | 3,036 | $89.63 | $272.12kSell |
| James Richard Porter | President and CEO | 2026-06-08 | 12,495 | $87.97 | $1.10MSell |
| James Richard Porter | President and CEO | 2026-06-08 | 14,469 | $88.79 | $1.28MSell |
| James Richard Porter | President and CEO | 2026-06-08 | 30,000 | $18.93 | $567.90kBuy |
| Alexandra Balcom | Chief Financial Officer | 2026-06-01 | 200 | $103.84 | $20.77kSell |
| Alexandra Balcom | Chief Financial Officer | 2026-06-01 | 2,170 | $95.99 | $208.30kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| James E. Flynn | 22.66% | 17,903,448 | $2.21B | Insider |
| Deerfield Management Company LP | 21.83% | 17,248,450 | $2.13B | Institution |
| Fmr LLC | 11.74% | 9,274,959 | $1.14B | Institution |
| Paradigm Biocapital Advisors LP | 6.74% | 5,324,433 | $656.98M | Institution |
| Blackrock Inc | 6.11% | 4,824,785 | $595.33M | Institution |
| Jpmorgan Chase Co | 3.91% | 3,088,349 | $381.07M | Institution |
| Ra Capital Management LP | 3.21% | 2,534,145 | $312.69M | Institution |
| Vanguard Portfolio Management LLC | 3.17% | 2,500,907 | $308.59M | Institution |
| Wellington Management Group LLP | 3.13% | 2,470,491 | $304.83M | Institution |
| Vanguard Capital Management LLC | 3.07% | 2,428,488 | $299.65M | Institution |