| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Mario Alberto Accardi | President Orexin Program | 2025-11-01 | 593 | $24.90 | $14.77kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-10-27 | 8,000 | $25.00 | $200.00kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-10-27 | 5,000 | $8.01 | $40.05kBuy |
| Iqbal J. Hussain | General Counsel | 2025-10-15 | 6,000 | $22.41 | $134.44kSell |
| Iqbal J. Hussain | General Counsel | 2025-10-15 | 6,000 | $5.84 | $35.04kBuy |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-09-24 | 35,000 | $9.42 | $329.70kBuy |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-09-24 | 35,000 | $24.00 | $840.00kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-09-16 | 742 | $22.02 | $16.34kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-09-16 | 7,430 | $21.33 | $158.50kSell |
| Iqbal J. Hussain | General Counsel | 2025-09-15 | 6,000 | $5.84 | $35.04kBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Medicxi Ventures Management Jersey Ltd | 14.89% | 19,963,157 | $473.93M | Institution |
| Index Venture Life Associates VI Ltd | 7.43% | 9,961,789 | $236.49M | Institution |
| General Atlantic LP | 7.22% | 9,681,818 | $229.85M | Institution |
| Gap Bermuda Ltd | 7.22% | 9,681,818 | $229.85M | Insider |
| Adage Capital Partners GP LLC | 6.27% | 8,403,000 | $199.49M | Institution |
| Janus Henderson Group PLC | 4.87% | 6,532,768 | $155.09M | Institution |
| Price T Rowe Associates Inc | 4.41% | 5,907,992 | $140.26M | Institution |
| Avoro Capital Advisors LLC | 3.73% | 5,000,000 | $118.70M | Institution |
| Farallon Capital Management LLC | 3.38% | 4,529,318 | $107.53M | Institution |
| First Light Asset Management LLC | 3.20% | 4,293,411 | $101.93M | Institution |