| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-17 | 40,000 | $28.00 | $1.12MSell |
| Iqbal J. Hussain | General Counsel | 2025-11-17 | 6,000 | $5.84 | $35.04kBuy |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-17 | 40,000 | $9.42 | $376.80kBuy |
| Iqbal J. Hussain | General Counsel | 2025-11-17 | 6,000 | $27.64 | $165.83kSell |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-12 | 40,000 | $26.00 | $1.04MSell |
| Tia L. Bush | Chief Technology Quality Ofc | 2025-11-12 | 40,000 | $9.42 | $376.80kBuy |
| Mario Alberto Accardi | President Orexin Program | 2025-11-01 | 593 | $24.90 | $14.77kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-10-27 | 5,000 | $8.01 | $40.05kBuy |
| Mario Alberto Accardi | President Orexin Program | 2025-10-27 | 8,000 | $25.00 | $200.00kSell |
| Iqbal J. Hussain | General Counsel | 2025-10-15 | 6,000 | $22.41 | $134.44kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Medicxi Ventures Management Jersey Ltd | 14.85% | 19,963,157 | $590.11M | Institution |
| Avoro Capital Advisors LLC | 8.04% | 10,808,080 | $319.49M | Institution |
| Adage Capital Partners GP LLC | 7.46% | 10,035,000 | $296.63M | Institution |
| Index Venture Life Associates VI Ltd | 7.41% | 9,961,789 | $294.47M | Institution |
| Gap Bermuda Ltd | 7.20% | 9,681,818 | $286.19M | Insider |
| General Atlantic LP | 7.20% | 9,681,818 | $286.19M | Institution |
| Fmr LLC | 4.67% | 6,277,243 | $185.56M | Institution |
| Janus Henderson Group PLC | 4.02% | 5,408,199 | $159.87M | Institution |
| Price T Rowe Associates Inc | 3.57% | 4,804,056 | $142.01M | Institution |
| Farallon Capital Management LLC | 3.22% | 4,331,318 | $128.03M | Institution |