| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Iqbal J. Hussain | Chief Legal Officer | 2026-02-02 | 38,951 | $25.15 | $979.66kSell |
| Mario Alberto Accardi | Chief Executive Officer | 2026-02-01 | 2,915 | $24.57 | $71.62kSell |
| Tia L. Bush | Chief Technology Quality Ofc | 2026-02-01 | 8,549 | $24.57 | $210.05kSell |
| Iqbal J. Hussain | Chief Legal Officer | 2026-02-01 | 7,780 | $24.57 | $191.15kSell |
| Karen M. Anderson | Chief People Officer | 2026-02-01 | 10,606 | $24.57 | $260.59kSell |
| Gregory M. Weinhoff | Chief Business Officer | 2026-02-01 | 14,158 | $24.57 | $347.86kSell |
| Iqbal J. Hussain | Chief Legal Officer | 2026-01-30 | 1,010 | $25.01 | $25.26kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-12-09 | 2,568 | $29.21 | $75.01kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-12-09 | 7,432 | $28.70 | $213.28kSell |
| Mario Alberto Accardi | President Orexin Program | 2025-12-08 | 5,000 | $9.53 | $47.65kBuy |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Medicxi Ventures Management Jersey Ltd | 14.85% | 19,963,157 | $502.87M | Institution |
| Avoro Capital Advisors LLC | 8.04% | 10,808,080 | $272.26M | Institution |
| Adage Capital Partners GP LLC | 7.46% | 10,035,000 | $252.78M | Institution |
| Index Venture Life Associates VI Ltd | 7.41% | 9,961,789 | $250.94M | Institution |
| Gap Bermuda Ltd | 7.20% | 9,681,818 | $243.88M | Insider |
| General Atlantic LP | 7.20% | 9,681,818 | $243.88M | Institution |
| Fmr LLC | 4.67% | 6,277,243 | $158.12M | Institution |
| Janus Henderson Group PLC | 4.02% | 5,408,199 | $136.23M | Institution |
| Price T Rowe Associates Inc | 3.57% | 4,804,056 | $121.01M | Institution |
| Farallon Capital Management LLC | 3.22% | 4,331,318 | $109.11M | Institution |