| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Georgia Melenikiotou | Director | 2026-05-01 | 50 | $56.70 | $2.84kSell |
| Georgia Melenikiotou | Director | 2026-04-15 | 307 | $52.07 | $15.99kBuy |
| Casey M. Tansey | Director | 2026-04-15 | 308 | $52.07 | $16.04kBuy |
| Shelley G. Broader | Director | 2026-04-15 | 342 | $52.07 | $17.81kBuy |
| Gary Lee Ellis | Director | 2026-04-15 | 518 | $52.07 | $26.97kBuy |
| John Rondoni | Title Chief Product and Innovation Officer. | 2026-02-20 | 735 | $59.53 | $43.75kSell |
| Timothy P. Herbert | CEO and President | 2026-02-20 | 4,010 | $59.53 | $238.72kSell |
| Carlton Weatherby | Chief Strategy and Growth Officer. | 2026-02-20 | 672 | $59.53 | $40.00kSell |
| Bryan K. Phillips | Senior Vice President General Counsel Secretary and Chief Compliance Officer. | 2026-02-20 | 735 | $59.53 | $43.75kSell |
| John Rondoni | Title Chief Product and Innovation Officer.Exhibit 24 - Power of Attorney. | 2026-02-13 | 587 | $59.76 | $35.08kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Blackrock Inc | 12.32% | 3,550,848 | $161.81M | Institution |
| Presidio Management Group IX LLC | 11.66% | 3,359,107 | $153.07M | Insider |
| Vanguard Group Inc | 10.25% | 2,953,170 | $134.58M | Institution |
| Orbimed Advisors LLC | 8.49% | 2,446,005 | $111.46M | Insider |
| Wellington Management Group LLP | 7.67% | 2,211,091 | $100.76M | Institution |
| Mudit K. Jain | 7.28% | 2,096,810 | $95.55M | Insider |
| Synergy Life Science Partners L P | 7.27% | 2,095,507 | $95.49M | Insider |
| Kleiner Perkins Caufield Byers XII LLC | 6.72% | 1,937,244 | $88.28M | Insider |
| Deerfield Management Company LP | 5.23% | 1,505,872 | $68.62M | Institution |
| Amzak Health Investors LLC | 5.20% | 1,497,043 | $68.22M | Insider |