| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Michael F. MacLean | Chief Financial Officer | 2026-01-21 | 2,735 | $72.45 | $198.15kSell |
| Sarah Boyce | President and CEO | 2026-01-21 | 6,394 | $72.45 | $463.25kSell |
| Sarah Boyce | President and CEO | 2026-01-21 | 7,993 | $72.45 | $579.09kSell |
| Steven George Hughes | Chief Medical Officer | 2026-01-21 | 2,017 | $72.45 | $146.13kSell |
| Steven George Hughes | Chief Medical Officer | 2026-01-21 | 2,878 | $72.45 | $208.51kSell |
| Arthur A. Levin | Director | 2026-01-21 | 1,758 | $72.45 | $127.37kSell |
| W. Michael Flanagan | Chief Scientific Officer | 2026-01-21 | 3,976 | $72.45 | $288.06kSell |
| W. Michael Flanagan | Chief Scientific Officer | 2026-01-21 | 2,558 | $72.45 | $185.33kSell |
| Michael F. MacLean | Chief Financial Officer | 2026-01-21 | 1,807 | $72.45 | $130.92kSell |
| Teresa McCarthy | Chief Human Resources Officer | 2026-01-21 | 1,453 | $72.45 | $105.27kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Fmr LLC | 14.33% | 21,585,984 | $1.57B | Institution |
| Janus Henderson Group PLC | 9.64% | 14,522,915 | $1.05B | Institution |
| Vanguard Group Inc | 8.77% | 13,219,759 | $959.36M | Institution |
| Rtw Investments LP | 7.55% | 11,372,829 | $825.33M | Institution |
| Wellington Management Group LLP | 6.68% | 10,065,187 | $730.43M | Institution |
| Price T Rowe Associates Inc | 6.50% | 9,787,417 | $710.27M | Institution |
| Blackrock Inc | 6.11% | 9,202,579 | $667.83M | Institution |
| Rtw Investments LP | 5.83% | 8,790,000 | $637.89M | Insider |
| Ra Capital Management LP | 5.73% | 8,641,031 | $627.08M | Institution |
| Avoro Capital Advisors LLC | 5.07% | 7,645,000 | $554.80M | Institution |