| Name | Hold | Shares | Value | Type | 
|---|---|---|---|---|
| Adage Capital Partners GP LLC | 6.13% | 6,601,938 | $17.50M | Institution | 
| Privium Fund Management Bv | 4.64% | 4,997,562 | $13.24M | Institution | 
| Affinity Asset Advisors LLC | 3.25% | 3,499,512 | $9.27M | Institution | 
| Morgan Stanley | 2.86% | 3,083,490 | $8.17M | Institution | 
| Sio Capital Management LLC | 1.93% | 2,075,139 | $5.50M | Institution | 
| Aberdeen Group PLC | 1.72% | 1,850,348 | $4.90M | Institution | 
| Kynam Capital Management LP | 1.53% | 1,649,462 | $4.37M | Institution | 
| Dafna Capital Management LLC | 1.46% | 1,567,561 | $4.15M | Institution | 
| Siren LLC | 1.44% | 1,552,183 | $4.11M | Institution | 
| Woodline Partners LP | 1.40% | 1,504,000 | $3.99M | Institution |