| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Lance G. Laing | Chief Science Officer | 2026-06-02 | 1,000 | $9.89 | $9.89kBuy |
| David Dalvey | Director | 2026-05-04 | 25,000 | $140.68 | $3.52MSell |
| Richard E. Buller | Director | 2026-05-04 | 365 | $143.24 | $52.28kSell |
| Richard E. Buller | Director | 2026-05-04 | 2,825 | $142.04 | $401.25kSell |
| Richard E. Buller | Director | 2026-05-04 | 2,301 | $141.03 | $324.50kSell |
| Richard E. Buller | Director | 2026-05-04 | 1,670 | $139.58 | $233.10kSell |
| Richard E. Buller | Director | 2026-05-04 | 550 | $139.00 | $76.45kSell |
| Richard E. Buller | Director | 2026-05-04 | 9,000 | $5.10 | $45.90kBuy |
| Richard E. Buller | Director | 2026-05-04 | 1,289 | $137.00 | $176.59kSell |
| Richard E. Buller | Director | 2026-03-31 | 2,325 | $110.11 | $256.00kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Baker Bros Advisors LP | 16.23% | 7,915,792 | $694.69M | Institution |
| Baker Bros Advisors LP | 14.79% | 7,211,484 | $632.88M | Insider |
| Avoro Capital Advisors LLC | 6.92% | 3,375,000 | $296.19M | Institution |
| Perceptive Advisors LLC | 6.41% | 3,127,200 | $274.44M | Institution |
| Brian F. Sullivan | 6.40% | 3,120,983 | $273.90M | Insider |
| Rtw Investments LP | 6.23% | 3,039,621 | $266.76M | Institution |
| Blackrock Inc | 5.56% | 2,711,532 | $237.96M | Institution |
| Nea Management Company LLC | 4.69% | 2,285,561 | $200.58M | Institution |
| Vanguard Capital Management LLC | 3.66% | 1,782,894 | $156.47M | Institution |
| Deerfield Management Company LP | 3.51% | 1,714,000 | $150.42M | Institution |