| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Julia Madsen | Sr. VP and GM Life Sciences | 2025-11-21 | 2,872 | $262.00 | $752.46kSell |
| Julia Madsen | Sr. VP and GM Life Sciences | 2025-11-21 | 2,872 | $114.22 | $328.04kBuy |
| Julia Madsen | Sr. VP and GM Life Sciences | 2025-11-21 | 2,136 | $147.05 | $314.10kBuy |
| Julia Madsen | Sr. VP and GM Life Sciences | 2025-11-21 | 2,136 | $262.00 | $559.63kSell |
| Renato Tamaro | V.P. Corporate Treasurer | 2025-11-18 | 3,536 | $182.22 | $644.33kBuy |
| Renato Tamaro | V.P. Corporate Treasurer | 2025-11-18 | 1,500 | $257.76 | $386.64kSell |
| Renato Tamaro | V.P. Corporate Treasurer | 2025-11-18 | 212 | $258.03 | $54.70kSell |
| Renato Tamaro | V.P. Corporate Treasurer | 2025-11-18 | 3,324 | $257.43 | $855.70kSell |
| John Adam Zangerle | Sr. VP Gen Counsel and Sec. | 2025-11-11 | 15,000 | $69.72 | $1.05MBuy |
| John Adam Zangerle | Sr. VP Gen Counsel and Sec. | 2025-11-11 | 15,000 | $265.14 | $3.98MSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Vanguard Group Inc | 12.44% | 12,213,521 | $3.16B | Institution |
| Blackrock Inc | 8.92% | 8,759,337 | $2.27B | Institution |
| Massachusetts Financial Services Co | 4.94% | 4,846,124 | $1.25B | Institution |
| State Street Corp | 4.44% | 4,354,839 | $1.13B | Institution |
| Morgan Stanley | 4.27% | 4,188,200 | $1.08B | Institution |
| Generation Investment Management LLP | 3.04% | 2,984,939 | $772.62M | Institution |
| Geode Capital Management LLC | 2.56% | 2,509,469 | $649.55M | Institution |
| Orbis Allan Gray Ltd | 2.17% | 2,129,311 | $551.15M | Institution |
| Select Equity Group LP | 2.01% | 1,976,784 | $511.67M | Institution |
| Mitsubishi Ufj Asset Management Co Ltd | 1.60% | 1,567,238 | $405.66M | Institution |