| Name | Role | Date | Shares | Price | Value |
|---|---|---|---|---|---|
| Leslie V. Norwalk | Director | 2025-12-16 | 1,190 | $155.09 | $184.56kSell |
| Leslie V. Norwalk | Director | 2025-12-15 | 8,276 | $92.35 | $764.29kBuy |
| Leslie V. Norwalk | Director | 2025-12-15 | 1,724 | $84.95 | $146.45kBuy |
| Leslie V. Norwalk | Director | 2025-12-15 | 5,000 | $152.23 | $761.15kSell |
| Darin Lippoldt | Chief Legal Officer | 2025-12-08 | 4,376 | $159.65 | $698.62kSell |
| Darin Lippoldt | Chief Legal Officer | 2025-12-08 | 4,376 | $43.24 | $189.22kBuy |
| Gary A. Lyons | Director | 2025-12-03 | 15,000 | $47.89 | $718.35kBuy |
| Gary A. Lyons | Director | 2025-12-03 | 15,000 | $152.61 | $2.29MSell |
| Jude Onyia | Chief Scientific Officer | 2025-11-29 | 2,248 | $152.16 | $342.06kSell |
| Eric Benevich | Chief Commercial Officer | 2025-11-28 | 5,970 | $151.74 | $905.88kSell |
| Name | Hold | Shares | Value | Type |
|---|---|---|---|---|
| Bvf Partners L P | 35.16% | 35,058,600 | $5.21B | Insider |
| Blackrock Inc | 12.74% | 12,706,230 | $1.89B | Institution |
| Vanguard Group Inc | 9.74% | 9,706,559 | $1.44B | Institution |
| Dodge Cox | 5.57% | 5,556,618 | $826.49M | Institution |
| Jpmorgan Chase Co | 4.74% | 4,730,152 | $703.56M | Institution |
| State Street Corp | 4.36% | 4,346,479 | $646.50M | Institution |
| Price T Rowe Associates Inc | 2.88% | 2,866,731 | $426.40M | Institution |
| Aqr Capital Management LLC | 2.78% | 2,773,648 | $412.55M | Institution |
| Renaissance Technologies LLC | 2.43% | 2,418,297 | $359.70M | Institution |
| Geode Capital Management LLC | 2.03% | 2,024,825 | $301.17M | Institution |