Sectors & IndustriesHealthcareBiotechnology
Best Biotech Stocks to Buy Now (2025)
Top biotech stocks in 2025 ranked by overall Zen Rating. "A" Rated stocks have returned an average of +32.52% per year, and are the best biotech stocks to buy now. Learn More.

Industry: Biotechnology
F
Biotech is Zen Rated F and is the 133rd ranked industry out of 145 stock market industries
Learn how the Zen Ratings work
Ticker
Company
Zen Rating
Financials
Market Cap
ROE
ROA
ROCE
ROIC
D/E
Current Ratio
Gross Margin
Profit Margin
Operating Margin
SLXN
SILEXION THERAPEUTICS CORP
$8.79M-1,666.00%-331.90%-267.26%-838.50%0.673.97N/AN/AN/A
ALMS
ALUMIS INC
$1.20B-75.50%-57.60%-60.04%-105.60%0.276.01100.00%-1,108.20%-1,146.94%
PALI
PALISADE BIO INC
$289.07M-240.70%-137.30%-320.89%577.10%1.171.96N/AN/AN/A
SPRB
SPRUCE BIOSCIENCES INC
$89.27M-305.40%-168.00%-762.62%955.90%1.841.54100.00%-6,869.30%-6,440.17%
NAUT
NAUTILUS BIOTECHNOLOGY INC
$233.66M-33.30%-28.40%-32.73%-29.60%0.1914.96N/AN/AN/A
MNPR
MONOPAR THERAPEUTICS
$498.55M-25.70%-24.80%-13.73%-155.60%0.0256.10N/AN/AN/A
SAVA
CASSAVA SCIENCES INC
$141.54M-95.80%-75.30%-129.80%2,002.20%0.592.27N/AN/AN/A
RARE
ULTRAGENYX PHARMACEUTICAL INC
$3.50B-436.00%-43.70%-67.82%-38.30%543.901.8984.70%-91.90%-91.46%
LTRN
LANTERN PHARMA INC
$40.26M-126.00%-97.40%-197.36%-232.80%0.423.33N/AN/AN/A
HYFT
MINDWALK HOLDINGS CORP
$81.69M-114.30%-61.20%-134.12%-119.00%0.962.1756.70%-130.20%-143.91%
KYMR
KYMERA THERAPEUTICS INC
$6.45B-33.40%-28.60%-28.61%-33.60%0.177.38100.00%-674.80%-674.04%
TAOX
TAO SYNERGIES INC
$42.92M-244.20%-152.10%-153.61%-540.70%0.1117.61100.00%-13,058.70%-12,829.93%
TPST
TEMPEST THERAPEUTICS INC
$13.81M-310.90%-125.10%-261.69%-289.60%1.702.30N/AN/AN/A
KPTI
KARYOPHARM THERAPEUTICS INC
$118.50MN/A-101.10%-883.59%-45.00%-1.361.0395.90%-87.40%-56.26%
CVM
CEL SCI CORP
$43.77M-259.40%-107.20%-167.96%-105.40%1.900.47N/AN/AN/A
EPRX
EUPRAXIA PHARMACEUTICALS INC
$225.47M-67.40%-65.30%-33.21%20,901.30%0.0423.98N/AN/AN/A
PTGX
PROTAGONIST THERAPEUTICS INC
$5.96B6.90%6.30%7.32%8.50%0.0913.05100.00%21.90%22.98%
LIXT
LIXTE BIOTECHNOLOGY HOLDINGS INC
$23.10M-219.00%-178.10%-82.92%-1,205.80%0.1110.42N/AN/AN/A
ESLA
ESTRELLA IMMUNOPHARMA INC
$65.33MN/A-446.70%137.24%246.60%-1.360.15N/AN/AN/A
CGEM
CULLINAN THERAPEUTICS INC
$704.19M-42.10%-39.80%-48.01%-49.30%0.0710.45N/AN/AN/A
WVE
WAVE LIFE SCIENCES LTD
$2.77B-75.60%-43.00%-78.43%504.40%0.882.51100.00%-111.60%-111.64%
IRD
OPUS GENETICS INC
$162.76M-774.20%-170.70%-968.51%467.50%5.051.24100.00%-466.10%-465.63%
INMB
INMUNE BIO INC
$53.44M-172.00%-134.50%-191.87%1,346.60%0.314.17100.00%-99,774.00%-99,774.00%
THAR
THARIMMUNE INC
$83.76M-588.40%-264.40%-167.25%641.10%0.254.99N/AN/AN/A
RCUS
ARCUS BIOSCIENCES INC
$2.32B-68.20%-31.30%-44.93%-44.90%1.233.65100.00%-142.10%-138.33%
EVMN
EVOMMUNE INC
$567.75MN/AN/AN/AN/A-0.067.87N/AN/AN/A
MAZE
MAZE THERAPEUTICS INC
$1.87B-65.20%-31.20%-31.61%-208.60%0.1117.70N/AN/AN/A
PYXS
PYXIS ONCOLOGY INC
$267.74M-102.10%-74.40%-114.78%-85.40%0.544.29100.00%-3,442.80%-3,509.47%
GOSS
GOSSAMER BIO INC
$833.24MN/A-59.70%-100.61%-38.50%-3.543.28100.00%-354.50%-335.05%
RAPP
RAPPORT THERAPEUTICS INC
$1.44B-28.60%-27.20%-18.75%-38.90%0.0536.37N/AN/AN/A
BNTC
BENITEC BIOPHARMA INC
$405.67M-45.90%-44.00%-41.64%2,647.30%0.0346.95N/AN/AN/A
KALV
KALVISTA PHARMACEUTICALS INC
$854.74MN/AN/AN/AN/A19.007.22N/AN/AN/A
STOK
STOKE THERAPEUTICS INC
$1.85B13.30%11.40%8.62%16.40%0.176.53100.00%19.70%13.35%
TLSA
TIZIANA LIFE SCIENCES LTD
$198.40M-250.50%-101.10%-425.46%-666.20%1.871.02N/AN/AN/A
TYRA
TYRA BIOSCIENCES INC
$1.21B-35.80%-33.60%-39.05%-47.60%0.0817.71N/AN/AN/A
SLRX
SALARIUS PHARMACEUTICALS INC
$4.57M-401.00%-155.80%-117.81%443.70%0.443.28N/AN/AN/A
ACXP
ACURX PHARMACEUTICALS INC
$8.49M-362.10%-175.30%-252.13%359.90%0.682.47N/AN/AN/A
AMLX
AMYLYX PHARMACEUTICALS INC
$1.44B-68.90%-61.50%-44.49%-128.50%0.0913.70100.00%22,448.40%22,543.91%
GNLX
GENELUX CORP
$164.00M-129.30%-97.40%-160.49%-169.50%0.344.20N/AN/AN/A
PTHS
PELTHOS THERAPEUTICS INC
$70.39M-210.30%-72.80%-21.88%-431.20%1.172.0168.70%-318.40%-300.30%
NTLA
INTELLIA THERAPEUTICS INC
$1.04B-57.20%-44.60%-53.61%-51.60%0.246.21100.00%-774.90%-774.94%
TSHA
TAYSHA GENE THERAPIES INC
$1.59B-67.30%-42.10%-34.68%-185.10%0.4510.48100.00%-1,583.70%-1,582.50%
TERN
TERNS PHARMACEUTICALS INC
$4.05B-30.00%-28.50%-32.91%-55.60%0.0619.52N/AN/AN/A
MCRB
SERES THERAPEUTICS INC
$153.25M15.30%3.60%4.46%3.60%2.282.30100.00%1,536.80%1,536.75%
EWTX
EDGEWISE THERAPEUTICS INC
$2.50B-30.90%-29.40%-27.99%-33.30%0.0426.51N/AN/AN/A
PLRX
PLIANT THERAPEUTICS INC
$75.58M-71.50%-53.30%-66.51%-62.10%0.3813.94N/AN/AN/A
INKT
MINK THERAPEUTICS INC
$58.30MN/A-180.10%-807.47%238.30%-2.111.08N/AN/AN/A
IMRX
IMMUNEERING CORP
$392.59M-73.50%-65.00%-26.99%-1,472.40%0.0624.00N/AN/AN/A
ALLO
ALLOGENE THERAPEUTICS INC
$339.34M-57.80%-43.10%-51.66%-53.00%0.408.19N/AN/AN/A
IMNM
IMMUNOME INC
$1.79B-87.20%-75.60%-83.13%-373.20%0.138.90100.00%-2,301.30%-2,301.30%
NNVC
NANOVIRICIDES INC
$22.50M-95.80%-83.80%-113.25%-138.60%0.171.06N/AN/AN/A
ELVN
ENLIVEN THERAPEUTICS INC
$1.00B-24.90%-24.00%-20.41%-34.80%0.0332.95N/AN/AN/A
OMER
OMEROS CORP
$719.64MN/A-53.90%-121.65%-23.80%-1.840.89N/AN/AN/A
LENZ
LENZ THERAPEUTICS INC
$567.60M-29.60%-27.90%-30.03%-33.60%0.0912.69100.00%-336.50%-333.61%
KYTX
KYVERNA THERAPEUTICS INC
$384.53M-77.90%-65.80%-104.98%-103.60%0.235.16N/AN/AN/A
PROK
PROKIDNEY CORP
$664.84MN/A-18.10%-20.87%-24.90%-0.0310.32100.00%-9,547.40%-9,049.33%
TLX
TELIX PHARMACEUTICALS LTD
$3.02B13.90%5.20%7.84%27.90%1.672.7865.10%6.40%11.87%
GPCR
STRUCTURE THERAPEUTICS INC
$4.06B-26.10%-24.70%-27.14%-31.10%0.0814.15N/AN/AN/A
IMMX
IMMIX BIOPHARMA INC
$237.40M-263.50%-120.00%-254.88%547.00%1.431.53N/AN/AN/A
CELZ
CREATIVE MEDICAL TECHNOLOGY HOLDINGS INC
$5.55M-88.90%-85.20%-106.61%3,830.80%0.0520.7160.00%-99,356.80%-99,356.80%
SION
SIONNA THERAPEUTICS INC
$1.91B-33.40%-22.70%-21.45%-27.40%0.0625.61N/AN/AN/A
HUMA
HUMACYTE INC
$245.33MN/A-27.90%-39.90%-24.80%-20.261.6260.50%-2,353.20%-1,674.35%
IMMP
IMMUTEP LTD
$376.78M-36.90%-34.30%-42.57%-130.80%0.0911.69100.00%-594.60%-594.28%
GLPG
GALAPAGOS NV
$2.09B-16.20%-11.30%-14.48%-14.00%0.448.6371.10%-151.40%-158.11%
ABCL
ABCELLERA BIOLOGICS INC
$1.08B-17.00%-12.60%-15.92%-17.70%0.4110.10100.00%-486.00%-580.13%
ABVX
ABIVAX SA
$7.96B-499.80%-96.70%-2,429.06%-391.00%-3.480.77100.00%-2,530.60%-2,293.15%
DSGN
DESIGN THERAPEUTICS INC
$537.17M-30.60%-29.20%-33.62%-32.80%0.0618.71N/AN/AN/A
VNDA
VANDA PHARMACEUTICALS INC
$368.17M-16.80%-13.40%-22.17%-33.30%0.293.1294.40%-39.70%-50.52%
ARMP
ARMATA PHARMACEUTICALS INC
$214.35MN/A-54.50%63.18%-29.50%-1.940.12100.00%-3,797.70%-2,580.16%
COGT
COGENT BIOSCIENCES INC
$6.00B-126.20%-89.70%-80.45%-153.00%0.416.38N/AN/AN/A
APLM
APOLLOMICS INC
$17.71M-233.70%-157.30%-937.36%2,070.90%1.691.39N/AN/AN/A
LEXX
LEXARIA BIOSCIENCE CORP
$29.78M-187.00%-162.00%-443.82%-2,392.90%0.532.3299.60%-1,686.00%-1,686.00%
VALN
VALNEVA SE
$704.80M-58.90%-21.50%-24.13%-19.10%1.981.7845.40%-56.80%-39.94%
LNAI
LUNAI BIOWORKS INC
$25.07M-385.10%-214.50%1,021.63%738.00%-1.530.04N/AN/AN/A
DYN
DYNE THERAPEUTICS INC
$2.75B-66.20%-56.30%-52.13%-146.40%0.2513.47N/AN/AN/A
CLNN
CLENE INC
$69.96MN/A-125.60%-200.24%-105.20%-2.811.5382.20%-14,250.50%-13,104.67%
CELC
CELCUITY INC
$4.87B-179.00%-58.00%-33.96%-41.30%3.0712.26N/AN/AN/A
KRRO
KORRO BIO INC
$77.50M-68.90%-45.90%-60.11%-49.60%0.636.71100.00%-1,199.50%-1,198.11%
MPLT
MAPLIGHT THERAPEUTICS INC
$939.22MN/AN/AN/AN/A-0.0913.22N/AN/AN/A
TELO
TELOMIR PHARMACEUTICALS INC
$49.85M-566.60%-447.90%-161.29%2,487.30%0.0617.51N/AN/AN/A
GANX
GAIN THERAPEUTICS INC
$149.44M-341.30%-174.10%-266.08%1,085.50%0.862.52N/AN/AN/A
CTNM
CONTINEUM THERAPEUTICS INC
$339.39M-32.30%-30.30%-32.19%-35.60%0.0629.07N/AN/AN/A
ABOS
ACUMEN PHARMACEUTICALS INC
$129.63M-97.40%-70.40%-107.41%-81.60%0.536.02N/AN/AN/A
RVPH
REVIVA PHARMACEUTICALS HOLDINGS INC
$76.51M-20,541.50%-187.50%-494.36%222.10%2.151.39N/AN/AN/A
BCYC
BICYCLE THERAPEUTICS PLC
$516.79M-35.50%-29.20%-36.37%-763.20%0.2410.66100.00%-884.50%-891.54%
FDMT
4D MOLECULAR THERAPEUTICS INC
$619.34M-47.30%-42.40%-54.07%-54.60%0.158.42100.00%-174,314.20%-174,314.17%
LCTX
LINEAGE CELL THERAPEUTICS INC
$382.34M-118.80%-66.80%-84.30%3,452.30%3.124.5097.80%-625.50%-625.53%
RNTX
REIN THERAPEUTICS INC
$40.74M-118.70%-102.00%-125.99%1,317.70%0.160.90N/AN/AN/A
ALEC
ALECTOR INC
$162.64M-123.00%-27.50%-42.18%-38.10%4.813.76100.00%-156.00%-155.96%
ELTX
ELICIO THERAPEUTICS INC
$143.15M-5,657.90%-160.70%-205.92%-320.10%6.413.30N/AN/AN/A
ORKA
ORUKA THERAPEUTICS INC
$1.46B-25.80%-24.80%-20.81%-31.60%0.0516.94N/AN/AN/A
IOBT
IO BIOTECH INC
$58.13M-465.40%-180.60%-407.32%5,856.20%42.862.01N/AN/AN/A
ACRV
ACRIVON THERAPEUTICS INC
$79.83M-53.70%-48.30%-62.69%-69.00%0.138.75N/AN/AN/A
HURA
TUHURA BIOSCIENCES INC
$52.54M-221.90%-141.90%-178.58%-2,355.40%0.530.40N/AN/AN/A
PGEN
PRECIGEN INC
$1.31B-5,766.20%-311.30%-176.76%-238.60%3.094.0430.30%-6,750.10%-3,899.94%
DTIL
PRECISION BIOSCIENCES INC
$66.15M-213.80%-72.20%-104.61%-207.20%4.623.45100.00%-11,977.40%-11,767.34%
MIST
MILESTONE PHARMACEUTICALS INC
$205.26M-2,372.70%-85.10%-70.24%-73.30%3.288.24N/AN/AN/A
PRAX
PRAXIS PRECISION MEDICINES INC
$6.72B-66.90%-60.30%-79.49%-115.20%0.155.18100.00%-3,658.50%-3,658.53%
XFOR
X4 PHARMACEUTICALS INC
$341.88M-343.70%-69.80%-61.27%-78.30%1.655.6583.20%-279.90%-252.51%
QCLS
Q/C TECHNOLOGIES INC
$19.88M-121.40%-48.90%-25.40%-419.50%1.111.71N/AN/AN/A

Biotech Stocks FAQ

What are the best biotech stocks to buy right now in Dec 2025?

According to Zen Ratings, our proprietary rating system that evaluates 115 factors proven to drive growth in stocks and assigns each stock in our system an overall letter grade as well as 7 individual Component Grades for Value, Growth, Momentum, Sentiment, Safety, Financials, and proprietary AI algorithms, the 3 best biotechnology stocks to buy right now are:

1. Beone Medicines (NASDAQ:ONC)


Beone Medicines (NASDAQ:ONC) is the #1 top biotech stock out of 617 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Beone Medicines (NASDAQ:ONC) is: Value: B, Growth: A, Momentum: B, Sentiment: A, Safety: C, Financials: C, and AI: B.

Beone Medicines (NASDAQ:ONC) has a Due Diligence Score of 53, which is 30 points higher than the biotech industry average of 23.

ONC passed 18 out of 33 due diligence checks and has strong fundamentals. Beone Medicines has seen its stock return 76.99% over the past year, overperforming other biotech stocks by 122 percentage points.

Beone Medicines has an average 1 year price target of $390.88, an upside of 22.51% from Beone Medicines's current stock price of $319.06.

Beone Medicines stock has a consensus Strong Buy recommendation according to Wall Street analysts. Of the 8 analysts covering Beone Medicines, 75% have issued a Strong Buy rating, 25% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

2. Aurinia Pharmaceuticals (NASDAQ:AUPH)


Aurinia Pharmaceuticals (NASDAQ:AUPH) is the #2 top biotech stock out of 617 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Aurinia Pharmaceuticals (NASDAQ:AUPH) is: Value: B, Growth: C, Momentum: B, Sentiment: B, Safety: C, Financials: A, and AI: B.

Aurinia Pharmaceuticals (NASDAQ:AUPH) has a Due Diligence Score of 46, which is 23 points higher than the biotech industry average of 23.

AUPH passed 15 out of 33 due diligence checks and has strong fundamentals. Aurinia Pharmaceuticals has seen its stock return 63.57% over the past year, overperforming other biotech stocks by 109 percentage points.

Aurinia Pharmaceuticals has an average 1 year price target of $17.25, an upside of 8.83% from Aurinia Pharmaceuticals's current stock price of $15.85.

Aurinia Pharmaceuticals stock has a consensus Buy recommendation according to Wall Street analysts. Of the 4 analysts covering Aurinia Pharmaceuticals, 25% have issued a Strong Buy rating, 25% have issued a Buy, 50% have issued a hold, while 0% have issued a Sell rating, and 0% have issued a Strong Sell.

3. Innoviva (NASDAQ:INVA)


Innoviva (NASDAQ:INVA) is the #3 top biotech stock out of 617 with a Zen Rating of A. Stocks with a rating of A have had an average return of +32.52% per year. Learn more.

The Component Grade breakdown for Innoviva (NASDAQ:INVA) is: Value: A, Growth: C, Momentum: C, Sentiment: B, Safety: C, Financials: A, and AI: C.

Innoviva (NASDAQ:INVA) has a Due Diligence Score of 45, which is 22 points higher than the biotech industry average of 23.

INVA passed 14 out of 33 due diligence checks and has strong fundamentals. Innoviva has seen its stock return 11.21% over the past year, overperforming other biotech stocks by 56 percentage points.

Innoviva has an average 1 year price target of $32.00, an upside of 55.11% from Innoviva's current stock price of $20.63.

Innoviva stock has a consensus Buy recommendation according to Wall Street analysts. Of the 4 analysts covering Innoviva, 25% have issued a Strong Buy rating, 50% have issued a Buy, 0% have issued a hold, while 0% have issued a Sell rating, and 25% have issued a Strong Sell.

What are the biotech stocks with highest dividends?

Out of 4 biotech stocks that have issued dividends in the past year, the 3 biotech stocks with the highest dividend yields are:

1. Dominari Holdings (NASDAQ:DOMH)


Dominari Holdings (NASDAQ:DOMH) has an annual dividend yield of 12.13%, which is 9 percentage points higher than the biotech industry average of 2.94%.

Dominari Holdings's dividend payout ratio of 8.4% indicates that its high dividend yield is sustainable for the long-term.

2. Royalty Pharma (NASDAQ:RPRX)


Royalty Pharma (NASDAQ:RPRX) has an annual dividend yield of 2.29%, which is -1 percentage points lower than the biotech industry average of 2.94%. Royalty Pharma's dividend payout is stable, having never dropped by more than 10% in the last 10 years. Royalty Pharma's dividend has shown consistent growth over the last 10 years.

Royalty Pharma's dividend payout ratio of 49.4% indicates that its dividend yield is sustainable for the long-term.

3. Bio Techne (NASDAQ:TECH)


Bio Techne (NASDAQ:TECH) has an annual dividend yield of 0.55%, which is -2 percentage points lower than the biotech industry average of 2.94%. Bio Techne's dividend payout is not stable, having dropped more than 10% one times in the last 10 years. Bio Techne's dividend has not shown consistent growth over the last 10 years.

Bio Techne's dividend payout ratio of 64% indicates that its dividend yield is sustainable for the long-term.

Why are biotech stocks down?

Biotech stocks were down -0.42% in the last day, and up 0.28% over the last week. Sonnet Biotherapeutics Holdings was the among the top losers in the biotechnology industry, dropping -59.35% yesterday.

Sonnet BioTherapeutics Holdings shares are trading lower after the company announced its stockholders approved a business combination with Hyperliquid Strategies and Rorschach I.

What are the most undervalued biotech stocks?

Based on the Valuation rating, one of the 7 components of a stocks overall Zen Ratings grade, which evaluates factors including estimated earnings yield, earnings before interest and taxes/enterprise value, cash flow yield, free cash flow to price, and price-to-earnings growth (PEG ratio), the 3 most undervalued biotech stocks right now are:

1. Harmony Biosciences Holdings (NASDAQ:HRMY)


Harmony Biosciences Holdings (NASDAQ:HRMY) is the most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Harmony Biosciences Holdings has a valuation score of 57, which is 42 points higher than the biotech industry average of 15. It passed 4 out of 7 valuation due diligence checks.

Harmony Biosciences Holdings's stock has gained 27.15% in the past year. It has overperformed other stocks in the biotech industry by 72 percentage points.

2. Puma Biotechnology (NASDAQ:PBYI)


Puma Biotechnology (NASDAQ:PBYI) is the second most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Puma Biotechnology has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

Puma Biotechnology's stock has gained 100.68% in the past year. It has overperformed other stocks in the biotech industry by 146 percentage points.

3. Innoviva (NASDAQ:INVA)


Innoviva (NASDAQ:INVA) is the third most undervalued biotech stock based on its Valuation Rating of A. Valuation is one of 7 Component Grades used to calculate the overall Zen Rating.

Innoviva has a valuation score of 43, which is 28 points higher than the biotech industry average of 15. It passed 3 out of 7 valuation due diligence checks.

Innoviva's stock has gained 11.21% in the past year. It has overperformed other stocks in the biotech industry by 56 percentage points.

Are biotech stocks a good buy now?

59.96% of biotech stocks rated by analysts are a strong buy right now. On average, analysts expect biotech stocks to rise by 47.99% over the next year.

3.31% of biotech stocks have a Zen Rating of A (Strong Buy), 6.42% of biotech stocks are rated B (Buy), 44.93% are rated C (Hold), 32.3% are rated D (Sell), and 13.04% are rated F (Strong Sell).

What is the average p/e ratio of the biotechnology industry?

The average P/E ratio of the biotechnology industry is 155.66x.
WallStreetZen does not provide financial advice and does not issue recommendations or offers to buy stock or sell any security.

Information is provided 'as-is' and solely for informational purposes and is not advice. WallStreetZen does not bear any responsibility for any losses or damage that may occur as a result of reliance on this data.